대한본초학회지 (The Korea Journal of Herbology)
- 제20권2호
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- Pages.115-125
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- 2005
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
원지(遠志)가 NMDA로 유발된 선경세포 손상에 미치는 효과
A Study on the Protective Effects of Polygalae Radix on Neurotoxicity Induced by N-methyl-D-aspartic acid(NMDA)
- Lee, Soo-Bae (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
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Seong, Nak-Sul
(National Crop Experiment Station, RDA) ;
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Lee, Young-Jong
(Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
- 발행 : 2005.06.30
초록
Objectives : Polygalae Radix (PR) from Polygalae tenuifolia (Polygalaceae) has been clinically used as a sedative, anti-inflammatory, and anti-bacterial agent. To extend pharmacological effects of PR in the central nervous system (CNS) on the basis of its CNS protective effect, the present study was conducted to identify the effect of PR, whether it shows the neuroprotective action against excitatory neurotoxicity. Methods : To identify the protective effect of PR to excitatory neuro-toxic agent, the present study was focused on the PR effect on cell death, that was caused by applying NMDA to nerve cell, elevation of
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