The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effect of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparat On Prevention of Osteoporosis In Ovariectomized Rats

생하수오(生何首烏)와 제하수오(製何首烏)가 난소적출(卵巢摘出)로 유발된 흰쥐의 골다공증(骨多孔症) 예방효과에 미치는 영향

  • Seo, Bu-Il (College of Oriental Medicine, Daegu Haany University) ;
  • Park, Ji-Ha (College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Eun-Sook (College of Oriental Medicine, Daegu Haany University) ;
  • Choi, Do-Jeom (College of Oriental Medicine, Daegu Haany University) ;
  • Choi, Hong-sik (College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Ho-Kyoung (Korea Institute of Oriental Medicine) ;
  • Seo, Young-Bae (College of Oriental Medicine, Daejeon University) ;
  • Kim, In-Rak (College of Oriental Medicine, Dongeui University) ;
  • Park, Jin-Hee (College of Oriental Medicine, Dongeui University) ;
  • Seo, Gyoo-Tae (College of Oriental Medicine, Daegu Haany University)
  • Published : 2005.06.30
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Abstract

Objectives : The present study has been undertaken to investigate the effects of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparat on prevention of osteoporosis in ovariectomized rats. Method : In this experiment, the rats were ovariectomized. Rats were administered by 2 kinds of medicine, Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparat. Results : The levels of spinal bone mineral density was significantly increased in comparison with OVX group at 6 weeks in Polygoni Multiflori Radix Preparat group. The levels of serum osteoclacin and calcium didn't show significant changes in comparison with OVX group in Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparat group. The levels of serum ALP showed significant decrease in comparison with OVX group at 3 weeks in Polygoni Multiflori Radix group, and showed significant decrease in comparison with OVX group at 6 weeks in Polygoni Multiflori Radix Preparat group. The levels of serum phosphorus showed significant decrease in comparison with OVX group at 3, 6 weeks in Polygoni Multiflori Radix, and showed significant decrease in comparison with OVX group at 6 weeks in Polygoni Multiflori Radix Preparat group. The levels of urine calcium and phosphorus didn't show significant changes in comparison with OVX group in Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparat group. The levels of femoral and fibula-tibial calcium showed significant increase in comparison with OVX group in Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparat group. The levels of femoral phosphorus showed significant increase in comparison with OVX group in Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparat group. The levels of femoral and fibula-tibial ash weight showed significant increase in comparison with OVX group in Polygoni Multiflori Radix Preparat group. And the levels of fibula-tibial ash weight showed significant increase in comparison with OVX group in Polygoni Multiflori Radix group. The levels of body weight and uterus weight didn't show significant changes in comparison with OVX group in Polygoni Multiflon Radix and Polygoni Multiflori Radix Preparat group. Conclusion : Reviewing these experimetal results, it appears that Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparat have efficacy on prevention of osteoporosis. In particular Polygoni Multiflori Radix Preparat showed good efficacy in comparison with Polygoni Multiflori Radix Preparat.

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