Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Immuno Modulatory Effect of Astragali Radix on OVA Induced Allergic Mouse Model

황기의 알러지 비염 동물실험에 대한 면역조절 효과

  • Kang, Hee (Department of Oriental Medicine, Kyunghee University) ;
  • Kim, Yoon-Bum (Department of Opthalmotolaryngology & Dermatology, College of Oriental Medicine, Kyunghee University) ;
  • Ahn, Kyoo-Seok (Department of Oriental Medicine, Kyunghee University)
  • 강희 (경희대학교 한의과대학 병리학교실) ;
  • 김윤범 (경희대학교 한의과대학 안이비인후피부과학교실) ;
  • 안규석 (경희대학교 한의과대학 병리학교실)
  • Published : 2005.06.25
Download PDF
⟨ Previous Next ⟩

Abstract

Astragali Radix(AR), is a popular tonic herb prescribed for 'insufficient qi' in Korea, Japan and China. The present study examined the effect of AR ethanol extract on ovalubumin induced allergic mouse model. AR administration reduced levels of IFN-gamma, Interleukin(IL)-4, IL-5 and total IgE in the OVA induced allergic inflammation. It also protected the upper airway respiratory epithelium from being damaged by the OVA induced inflammation. Taken together, our results showed that the use of AR alone proved to down-regulate Th1 and Th2 cytokine production and play a protective role in tissue damage in allergic disease.

Keywords

References

  1. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic dermatitis; ISAAC. The Internatational Study of Asthma and Allergies in Childhood(ISAAC) Steering committee. Lancet, 351(9111):1225-1232, 1998. https://doi.org/10.1016/S0140-6736(97)07302-9
  2. Matsuda, H., Tewtrakul, S., Morikawa, T., Nakamura, A., Yoshikawa, M. Anti-allergic principles from Thai zedoary : structural reuirements of curcuminoids for inhibition of degranulation and effect on the release of TNA-$\alpha$ and IL-4 in RBL-sH3 cells. Bioorgnic & Medicinal chemistry, 12, 5891-5898, 2004.
  3. Romagnani, S. Regulation of the development of type 2 T helper cels in allergy. Curr Opin Immunol 6(6):833-846, 1994.
  4. 裴秉哲, 今釋 黃帝內經素問, 서울, 성보사, p 82, 1995.
  5. 전국한의과대학 공동교재편찬취원회, 본초학, 서울, 영림사, pp 579-581, 2004.
  6. Kobayashi, H., Mizuno, N., Kutsuna, H., Teramae. H., Ueoku, S., Onoyama, J., Yamanaka, K., Fujita, N., Ishii, M. Hochu-ekki-to suppresses development of dermatitis and elevation of serum IgE level in NC/Nga mouse. Drug Exp Clin Res., 29(2):81-84, 2003.
  7. Suzuki, T., Takano, I., Nagai, F., Ushiyma, K, Okubo, T., Seto, T., Ikeda, S., Kano, I. Suppressive effects of Hochu-ekki-to, a traditional Chinese medicine on IgE production and histamine release in mice immunized with ovalubumin. BioI. Pharm. Bull., 22, 1180-84, 1999.
  8. Kaneko, M. et aI. Suppression of IgE produciton in mice treated with a traditional Chinese medicine, bu-zhong-yi-qi-tang (Japanese name: hochu-ekki-to). Immunopharmacology, 36(1):79-85, 1997. https://doi.org/10.1016/S0162-3109(96)00162-2
  9. 강희, 배현수, 안규석. 황기에 의한 Helper T cell의 생존 및 활성 증가. 대한동의생리병리학회지, 15(4):560-565, 2001.
  10. Kang, H., Ahn, KS., Cho, CW., Bae, H.S. Immunomodulatory effect of Astragali Radix Extract on Murine Th1/Th2 Cell Lineage Development. BioI. Pharm. Bull. 27(12):1946-1950, 2004.
  11. Song, H.Q., Kobayashi, T., Xiu, LM., Hong, T., Cyong, J.C. Effects of Astragali root and Hedysari root on the murine Band T cell differentiation. J Ethnopharrnacol, 73, 111-119, 2000.
  12. Grewe, M., Bruijnzeel-Koomen, C.A.F.M., Schopf, E., Thepen, T. Langeveld-Wildschut, AG. A role for Th1 and Th2 cells in the immune-pathogenesis of atopic dermatitis. Immunol Today, 19, 359-361, 1998.
  13. Busse, W.W., Lernanske, R.F. Jr. Asthma. N Engl J Med., 344, 350-362, 2001.
  14. Lambrecht, B.N., De Veerman M, Coyle AJ., GutierrezRamos, J.C, Thielernans, K, Pauwels, RA Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest, 106, 551-559, 2000.
  15. Julia, V., Hessel, E.M., Malherbe, L., Glaichenhaus, N., O'Carra, A, Coffman, KL. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity, 16, 271-283, 2002.
  16. Lewis, D.B. Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy? Current Opinion in Immunology. 14, 644-651, 2002.
  17. Spergel, J.M., Mizoguchi, E., Oettgen, H., Bhan, AK, Ceha, R.5. Roles of Th1 and Th2 cytokines in a murine model of allergic dermatitis. J Clin Invest, 103, 1103-1111, 1999.
  18. Hofstra, CL., Van Ark I., Hofman, G.L Nijkamp, F.P., Jardieu, P.M., Van Oosterhout, A.J. Differential effects of endogenous and exogenous interferon-gamma on imunoglobulin E, celular infiltration, and aiway responsiveness in a murine model of allergic asthma. Am J Respir Cell Mol Biol. 19, 826-835, 1998.
  19. Tsitoura, D.C, Blumenthal, R.L., Berry, G., Dekruyff, R.H., Umetsu, D.T. Mechanisms preventing allergen-induced airways hyperreactivity: role of tolerance and immune deviation. J Allergy elin Immunol, 106, 239-246, 2000.
  20. Salvi, S.S., Babu, KS., Holgate, S.T. Is asthma really due to a polarized T cell responses toward a helper T cell type 2 phenotype? Am J Respir Crit Care med, 164, 1343-1346, 2001.
  21. Castro, M., Chaplin, D.D., Walter, M.J., Holtzman, M.J. Could asthma be worsened by stimulating the T-helper type 1 immune response? Am J respir Cell Mol Biol, 22, 143-146, 2000.
  22. Von Garnier, C., Astori, M., Kettner, A, Dufour, N. Heusser, C, Corradin, G., Spertini, F. Allergen-derived lonpeptide immunotherapy downregulates specific IgE response and protects from anaphylaxis. Eur J Immunol, 30, 1638-1645, 2000.
  23. Jarnicki, A.G., Tsuji, T., Thomas, W.R. Inhibition of mucosal and systemic Th2-type immune responses by intranasal peptides containing a dominant T cell epitope of the allergen Der p 1. Int Immunol 13, 1223-1231, 2001.
  24. Pedotti, R, Mitchell, D., Wedemeyer, J., Karpuj, M, Chabas, D., Hattab, E.M., Tsai, M., Galli, SJ., Steinman, L. An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide. Nat Immunol, 2, 216-222, 2001.
  25. Berish, L.C., Nelson, H.S., Corren, J., Bensch, G., Busse, W.W., Whitmore, J.B., Agosti, J.M. Efficacy of soluble IL-4rceptor for the treatment of adults with asthma. J Allergy Clin Immunol., 107, 963-970, 2001.
  26. Mattes, J., Yang, M., Siqueria, A, Clark, K, Mackenzie, J., McKenzie, A.N., Webb, D.C., Matthaei, K.I., Foster, P.S. IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung. J immunol., 167, 1683-1692, 2001.
  27. Milgrom, H., Berger, W., Nayak. A., Gupta, N., Pollard, S., McAlary, M., Talyor, A.F., Rohane, P. Treatment of childhood asthma with anti-immunoglobulin E antibody. Pediatrics, 108, E36, 2001.
  28. Casale, T.B., Condemi, J., Laforce, C, Nayak, A, Rowe, M., Watrous, M., McAlary, M., Fowler-Taylor, A, Racine, A, Gupta, N. Effect of omalizumab on symptoms of seasonal allergic rhinitis: a randomized controlled trial. J Am Med Assoc., 286, 2956-2967, 2001.
  29. Inagaki, N, Nagai, H. Drugs for the treatment of allergic disease. Jpn J Pharmacol 86, 275-280, 2001.
  30. Ikeda, Y., Kaneko, A., Yamamoto, M., Ishige, A., Sasaki, H. Possible involvement of suppression of Th2 differentiation in the anti-allergic effect of Sho-seiryu-to in mice. Jpn. J Pharmacol, 90, 328-336, 2002.
  31. Ishimitus, R., Nishira, H., Kawauchi, H., Kawakita, T., Yoshika, Y., Int. Immunopharmachol., 1, Dichotomous effect of a traditional Japanese medicine, bu-zhong-yi-ti-tang on allergic asthma in mice. Int. Immunopharmacol., 1, 857-865, 2001.
  32. Keith, I., Block, M.D., Mark, N., Mead, M.S. Immune system effects of Echinacea, Ginseng, and Astragalus: A Review. Intergrative Cancer Therapies 2(3):247-267, 2003.
  33. Yoshida, Y., Wang, M.Q., Liu, J.N., Shan, B.E., Yamashita, U. Immunomodulating activity of Chinese medicinal herbs and Oldelandia diffusa in particular. Int Immunopharmacol. 19(7):359-370.
  34. Zhao, K.S., Mancini, G., Doria, G., Enhancement of the immune response in mice by Astragalus membranaceous extracts. Immunopharmacology. 20(3):225-33, 1990.
  35. Wang, R.T., Shan, B.E., Li Q.X. Extracorporal experimental study on immuno-modulating activity of Astragalus membranaceus extract. Zhongguo Zhong Xi Yi Jie He Za Zhi. 22(6):453-56, 2002.
  36. Hou, Y.D., Ma, G.L, Wu, S.H., Li, Y.Y., Li, H.T., Effect of Radix Astragali seu Hedysari on the interferone system. Chin Med J. 94(1):35-40, 1981.