Korean Journal of Acupuncture
- Volume 22 Issue 3
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- Pages.119-135
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- 2005
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- 2287-3368(pISSN)
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- 2287-3376(eISSN)
The Experimental Study on the Suppressive Effect of Aristoltchiae Fructus Herbal-acupuncture at St36 on OVA-induced Asthma and the Regulatory Effect on Immune Response
마두영약침(馬兜鈴藥鍼)의 천식억제(喘息抑制) 및 면역조절효과(免疫調節效果)에 대(對)한 실험적(實驗的) 연구(硏究)
- Park, Jung-Jun (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University) ;
- Kim, Young-Il (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University) ;
- Lee, Hyun (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University)
- Published : 2005.09.27
Abstract
Objectives : The aim of this study was to investigate the Asthma-suppressive and Immune-regulatory effect of AF-HA(Aristolochiae Fructus Herbal-acupuncture) at Joksamni(St36) in OVA(ovalbumin) induced asthma mouse model. Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). The mice in the OVA-AF-HA group were treated with AF-HA at St36 for the later 8weeks(3times/week). The mice in the OVA-Needle-prick group were treated with single prick with an injection needle at St36 for the later 8 weeks(3times/week). Results : 1. The lung weight and the total cells in lung of the mice treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. 2. Total leukocytes and eosinophils in BALF of the mice group treated with AF-HA at St36 decreased remarkably compared with those of the OVA-control group. 3. The collagen accumulation in lung of OVA-AF-HA group decreased significantly compared with that of the OVA-control group, 4. The concentrations of IL-4, IL-5, IgE in BALF, and IL-4, IL-5, IL-13 in serum of the mice group treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. 5. The numbers of