족삼리(足三里)에 시술(施術)된 죽력(竹歷) 약침(藥鍼)이 Intraluminal Filament 삽입술(揷入術)에 의하여 유발(誘發)된 백서(白鼠)의 허혈성(虛血性) 국소(局所) 뇌손상(腦損傷)에 미치는 영향(影響)

Effects of BCL herbal acupuncture into Choksamni(ST36) on focal brain ischemic injury induced by intraluminal filament insertion in the rats

  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 이봄비 (경희대학교 동서의학대학원 침구경학학교실) ;
  • 심인섭 (가톨릭대학교 의과대학 통합의학교실) ;
  • 나창수 (동신대학교 한의과대학 경혈학교실)
  • Youn, Dae-Hwan (Dept. of Meridian and Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Lee, Bom-Bi (Dept. of Oriental Med. Science, Graduate School of East-West Med. Science, Kyung Hee University) ;
  • Shim, In-Sop (Dept. of Intergrative Midicine, College of Medicine, The Catholic University) ;
  • Na, Chang-Su (Dept. of Meridian and Acupoint, College of Oriental Medicine, Dongshin University)
  • 발행 : 2005.06.27

초록

Objectives : Bambusae Caulis in Liquamen(BCL) has been used to medication for early stroke in the Oriental Medicine. So this study was planned to investigate the effects of BCL on the focal ischemia-induced by intraluminal filament insertion in the rats. Materials and methods: The focal ischemia was induced by Intraluminal Filament insertion into middle cerebral artery. BCL herbal acupuncture at ST36 was carried out during 3 weeks after focal ischemia-induced. Eight-arm radial maze was used for the behavioral task and neuroprotective effect of BCL acupuncture was observed by Cresyl violet, AchE, ChAT-stain Results : The error rate in the eight-arm radial maze task was significantly decreased in BCL1(0.89mg/kg) herbal acupuncture group compared to control group on 3,4,5days, compared to saline acupuncture group on 3,5days. The rate of correct choice was significantly increased in saline acupuncture, BCL1 herbal acupuncture group, BCL2(0.089mg/kg) herbal acupuncture groups compared to control group. The density of neurons in the hippocampal CA1 was the most increased in BCL1 herbal acupuncture group compared to the others. The density of AchE in the hippocampal CA1 was significantly increased in BCL1 herbal acupuncture, BCL2 herbal acupuncture groups compared to control group, and in BCL2 herbal acupuncture groups increased compared to saline acupuncture, control groups. The density of ChAT in the hippocampal CA1 was significantly increased in BCLl herbal acupuncture group compared to saline acupuncture, control groups. Conclusions : These results suggest that BCL herbal acupuncture could be used as a medication for controlling the early stroke.

키워드