한국환경성돌연변이발암원학회지 (Environmental Mutagens and Carcinogens)

한국환경성돌연변이발암원학회 (Korean Environmental Mutagen Society)
권호 표지

Combined Effect of Radiation and $7{\beta}$-Hydroxycholeslerol on Human Cervical Cancer Cells in vitro

  • Chae, Sung-Wook (Department of Biochemistry College of Medicine and Applied Radiological Science Research Institute, Cheju National University) ;
  • Kang, Kyoung-Ah (Department of Biochemistry College of Medicine and Applied Radiological Science Research Institute, Cheju National University) ;
  • Lee, Kyoung-Hwa (Department of Biochemistry College of Medicine and Applied Radiological Science Research Institute, Cheju National University) ;
  • Zhang, Rui (Department of Biochemistry College of Medicine and Applied Radiological Science Research Institute, Cheju National University) ;
  • Jung, Myung-Sun (Department of Biochemistry College of Medicine and Applied Radiological Science Research Institute, Cheju National University) ;
  • Hyun, Jin-Won (Department of Biochemistry College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
  • 발행 : 2005.09.01
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초록

[ $7{\beta}$ ]-Hydroxycholesterol (cholest-5-ene-3, 7-diol, $7{\beta}$-OHC) showed the cytotoxicity on human cervical carcinoma cells (HeLa), $10{\mu}M$ of 50% inhibitory concentration. We evaluated $7{\beta}$-OHC as the possibility of radiation sensitizer. The combination effect of $7{\beta}-OHC\;and\;{\gamma}$-irradiation was measured using colony forming assay and flow cytometer with propidium iodide and $DiOC_6$ stained cells, respectively. The combined treatment of $7{\beta}-OHC\;and\;{\gamma}$-irradiation did not show significant enhancing effects on HeLa cells.

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