Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Simple Synthesis of Novel 1',4'-Dimethyl Branched Carbovir Analogues

  • Published : 2005.11.20
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Abstract

Novel 1',4'-dimethyl branched carbocyclic nucleosides were synthesized from acetol. The 4'-methyl group was installed via a Claisen rearrangement reaction, and the carbonyl addition of methylmagnesium bromide was used to introduce the 1'-methyl group. The coupling of nucleosidic bases and desilylation was used to produce a series of novel nucleosides.

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References

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