생명과학회지 (Journal of Life Science)

  • 제15권3호
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  • Pages.423-426
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  • 2005
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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황백나무로부터 생리활성물질인 alkaloids 화합물의 분리 및 탐색

Alkaloids from the Stem Bark of Phellodendron amurense Rupr

  • Lee Jin Hwan (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Lee Byong Won (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Kang Nam Suk (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Moon Yea Hwang (Department of Animal Science & Biotechnology, Jinju National University, RAIRC) ;
  • Yang Min Suk (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Park Ki Hun (Department of Agricultural Chemistry, Gyeongsang National University)
  • 발행 : 2005.06.01
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초록

운향과(Rutaceae)인 황백나무(Phellodendron nmurense Rupr.)의 줄기 점 질에서 2종의 isoquinoline 화합물과 1종의 quinolone 화합물을 분리하였다. Isoquinoline 화합물은 thalifoline (2)과 칼슘 방출을 저해하여 혈압조절에 관여하는 berberine (3)으로 구조동정 되었다. 또한 quinolone 화합물은 N-methylatanine (1)로 구조동정 되었다. 이들의 화합물 중에서 N-methylatanine (1)과 thalifoline (2)는 황백나무에서 처음으로 분리하였다.

Two isoquinolines and one quinolone were isolated from the stem bark of Pellodendron amurense Rupr. (Rutaceae). Two isoquinolines were elucidated as thalifoline (2) and pharmacological active berberine (3) has been blocking the release of $Ca^{2+}$ from internal stores. One quinolone was identified as N-methylatanine (1). This is the first report on the isolation of N-methylatanine (1) and thalifoline (2) from this plant.

키워드

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