Melanotrichia in Poodles : Clinical and Histopathological Findings

푸들에서 발생한 melanotrichia: 임상적 그리고 조직병리학적 특징

  • Kim Ha-jung (Department of Veterinary Internal Medicine, College of Veterinary Medicine) ;
  • Park Chul (Department of Veterinary Internal Medicine, College of Veterinary Medicine) ;
  • Jung Dong-in (Department of Veterinary Internal Medicine, College of Veterinary Medicine) ;
  • Kim Ju-won (Department of Veterinary Internal Medicine, College of Veterinary Medicine) ;
  • Kang Byeong-teck (Department of Veterinary Internal Medicine, College of Veterinary Medicine) ;
  • Im Chae Yeong (Department of Veterinary Internal Medicine, College of Veterinary Medicine) ;
  • Sur Jung-hwayang (Department of Veterinary Histopathology, College of Veterinary Medicine, Konkuk University) ;
  • Kim Chun-gun (Tae-il animal hospital) ;
  • Park Hee-myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine)
  • 김하정 (건국대학교 수의과대학 내과학 교실) ;
  • 박철 (건국대학교 수의과대학 내과학 교실) ;
  • 정동인 (건국대학교 수의과대학 내과학 교실) ;
  • 김주원 (건국대학교 수의과대학 내과학 교실) ;
  • 강병택 (건국대학교 수의과대학 내과학 교실) ;
  • 임채영 (건국대학교 수의과대학 내과학 교실) ;
  • 서정향 (건국대학교 수의과대학 조직 병리학 교실) ;
  • 김춘근 (서울 태일 동물병원) ;
  • 박희명 (건국대학교 수의과대학 내과학 교실)
  • Published : 2005.06.01

Abstract

A 5-year-old, female Poodle and her daughter, 2-year-old, were referred to Konkuk University Veterinary Teaching Hospital (KVTH) due to discoloration of hair on dorsum, and generalized alopecia following clipping. Some papules and pustules are found on patch area. Complete blood counts and serum chemistry profiles were not remarkable. Trichogram revealed that melanin-granule was pigmented on hair bulb and shaft in affected area and no melanin pigmentation was noted in non-patch area. And skin biopsy showed mild epidermal hyperplasia and mild inflammation in dermis of the patch area. This case report indicates that melanotrichia can be occurred by postclipping inflammation. However, the mechanism of melanocyte proliferation and rates of melanogenesis in response to postclipping remains to be unclear in these cases.

5살과 2살의 푸들 견이 미용 직후, 등 부위의 털의 변색과 전신적 탈모증세로 건국대학교 부속 동물 병원에 내원하였다 병변 부위에서는 육안적으로 약간의 피부 발적과 소농포가 발견되었지만 총 혈구 계산, 혈액 화학 검사에서는 특이한 소견이 발견되지 않았다. 아울러 최근 약물투여 병력도 없었다. 병변부의 trichogram에서는 모근 쪽과 모간에 멜라닌 과립이 착색되어 있었고, 병변 이외의 부위에서는 멜라닌 착색이 관찰되지 않았다. 그리고 병변부 피부 생검에서는 약한 부전 각화증이 관찰되었으며 아주 미약한 진피층의 호중구 침윤이 관찰되었다. 본 케이스에서는 melanotrichia가 미용 직후에 피부에 가해지는 각종 자극에 의해 발생할 수 있음을 보여주고 있다. 그러나, 미용 후 멜라닌 신생의 정도와 델라닌 세포의 증식 기전은 본 증례로서는 현재까지 명확하게 밝혀지지는 않았다.

Keywords

References

  1. Bergfeld WF, McMahon JT. Identification of foreign metallic substances inducing hypopigmentation of skin. Light microscopy, electron microscopy, and x-ray energy spectroscopic examination. In: Advances in Dermatology, Chicago: Year Book Medical Publishers. 1987; 2: 171-180
  2. Cribb AE. Idiosyncrayic reactions to sulfonamides in dogs. J Am Vet Med Assoc 1989; 195: 1612-1614
  3. Danny WS, William HM, Craig EG. In: Muller and Kirk's Small Animall Dermatology, 6th ed. Philadelphia: Saunders. 2001: 1005-1024
  4. Danny WS, William HM. Idiosyncratic cutaneous adverse drug reactions in the dogs: Literature review and report of 101 cases. Canine Prac 1999; 24: 16-22
  5. Eigenmann JE. Estrogen-induced flank alopecia in the female dog: Evidence for local rather than systemic hyperestrogenism. J Am Anim Hosp Assoc 1984; 20: 621-30
  6. Gross TL, Ihrke PJ, Walder EJ. In: Veterinary Dermatopathology. St Louis: Mosby-Year Book. 1992: 223-237
  7. Joseph JY, Joseph GM, Sandra JW, Kristen BR, David AN, Martin RZ. Cultured human keratinocytes synthesize and secrete endothelin-1. J Invest Dermatol 1993; 100: 23-26 https://doi.org/10.1111/1523-1747.ep12349932
  8. MacDonald JM. Hyperpigmentation. In: Current Veterinary Dermatology. St Louis: Mosby-Year Book. 1993: 234-244
  9. Mina Y, Barbara AG. Human Melanocyte growth and differentiation: A decade of new data. J Invest Dermatol 1991; 97: 611-617 https://doi.org/10.1111/1523-1747.ep12482985
  10. Walter BS, Howard MR, Grant M. Pyridoxine-dependent hair pigmentation in association with homocys-tinuria. Arch Dermatol 1972; 106: 228-230 https://doi.org/10.1001/archderm.106.2.228