Biomedical Science Letters (대한의생명과학회지)
- Volume 11 Issue 2
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- Pages.143-152
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- 2005
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
The Relationship between Urinary 8-hydroxydeoxyguanosine and Polycyclic Aromatic Hydrocarbons Exposure in Working Environment
- Lee Jong-Seong (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
- Kim Eun-A (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
- Lee Yong-Hag (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
- Moon Deog-Hwan (Institute of Industrial Medicine and Department of Occupational & Environmental Medicine, Inje University Paik Hospital) ;
- Kim Kwang-Jong (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
- Published : 2005.06.01
Abstract
To investigate the exposure effect of polycyclic aromatic hydrocarbons (PAHs), we analyzed the relationship between urinary 8-hydroxydeoxyguanosine (8-OHdG) concentration and PAHs exposure. The study population contained 44 workers in steel-pipe coating and paint manufacture industries. We measured airborne total PAHs as an external dose, urinary 1-hydroxypyrene (1-OHP) as an internal dose of PAHs exposure, and urinary 8-OHdG as an effective dose of oxidative DNA damage. There was significant correlation between the urinary concentration of l-OHP and the environmental concentration of PAHs, pyrene, urinary cotinine, AST, and GGT. The mean of urinary 8-OHdG was
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