Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Expression of Newer Outer Membrane Proteins (OMPs) Induced by Cephalosporins and Quinolone Group of Antibiotics in Klebsiella pneumoniae

  • KY TO (Department of Microbiology, Panjab University) ;
  • DANA VAN (Department of Microbiology, Panjab University) ;
  • SHARMA SAROJ (Department of Microbiology, Panjab University) ;
  • CHHIBBER SANJAY (Department of Microbiology, Panjab University)
  • Published : 2005.04.01
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Abstract

Effect of antibiotics belonging to three different groups, including third generation cephalosporins, aminoglycosides, and quinolones, on the outer membrane protein (OMP) profile of Klebsiella pneumoniae was examined. It was found that a new OMP (porins) of 40 kDa molecular mass was expressed in Klebsiella pneumoniae, when grown in the presence of ceftazidime, whereas new proteins with 30 kDa and 22 kDa masses were detected in the presence of ofloxacin. The immunoblot analysis showed that the new proteins of 40 kDa and 30 kDa molecular masses were expressed on the outer envelope, when being exposed to antibiotics ceftazidime and ofloxacin, respectively. This finding is important, as the outer surface comes in contact with the immune system, and therefore may have a bearing on the outcome of the disease.

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