References
- Agullo, G., Gamet-Payrastre, L., Manenti, S., Viala, C., Remesy, C., Chap, H., and Payrastre, B., Relationship between flavonoid structure and inhibition of phosphatidylinositol 3- kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem. Pharmacol., 53, 1649-1657 (1997) https://doi.org/10.1016/S0006-2952(97)82453-7
- Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S., Itoh, N., Shibuya, M., and Fukami, Y., Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem., 262: 5592-5595 (1987)
- Carter, A. B., Knudtson, K. L., Monick, M. M., and Hunninghake, G. W., The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP). J. Biol. Chem., 274, 30858- 30863 (1999a) https://doi.org/10.1074/jbc.274.43.30858
- Carter, A. B., Monick, M. M., and Hunninghake, G. W., Both Erk and p38 kinases are necessary for cytokine gene transcription. Am. J. Respir. Cell Mol. Biol., 20, 751-758 (1999b) https://doi.org/10.1165/ajrcmb.20.4.3420
- Cho, J. Y., Kim, P. S., Park, J., Yoo, E. S., Baik, K. U., Kim, Y. K., and Park, M. H., Inhibitor of tumor necrosis factor-alpha production in lipopolysaccharide-stimulated RAW264.7 cells from Amorpha fruticosa. J. Ethnopharmacol., 70, 127-133 (2000) https://doi.org/10.1016/S0378-8741(99)00154-3
-
Cho, J. Y., Kim, P. S., Park, J., Chae, S. H., Yoo. E. S., Baik, K. U., and Park, M. H., Inhibitory effect of medicinal plants on TNF-
$\alpha$ production from LPS-stimulated RAW264.7 cells. Nat. Prod. Sci., 5, 12-19 (1999) - Choi, J. S., Chung, H. Y., Kang, S. S., Jung, M. J., Kim, J. W., No, J. K., and Jung, H. A., The structure-activity relationship of flavonoids as scavengers of peroxynitrite. Phytother. Res., 16, 232-235 (2002) https://doi.org/10.1002/ptr.828
- Cobb, M. and Goldsmith, E., How MAP kinases are regulated. J. Biol. Chem., 270, 14843-14846 (1999)
- Cushman, M., Nagarathnam, D., Burg, D. L., and Geahlen, R. L., Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. J. Med. Chem., 34, 798-806 (1991) https://doi.org/10.1021/jm00106a047
- Faulkner, K. M., Liochev, S. I., and Fridovich, I., Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J. Biol. Chem., 269: 23471-23476 (1994)
- Geahlen, R. L., Koonchanok, N. M., McLaughlin, J. L., and Pratt, D. E., Inhibition of protein-tyrosine kinase activity by flavanoids and related compounds. J. Nat. Prod., 52, 982- 986 (1989) https://doi.org/10.1021/np50065a011
- Guha, M. and Mackman, N. LPS induction of gene expression in human monocytes. Cell Signal., 13, 85-94 (2001) https://doi.org/10.1016/S0898-6568(00)00149-2
- Haenen, G., Paquay, J., Korthouwer, R., and Bast, A., Peroxynitrite scavenging by flavonoids. Biochem. Biophys. Res. Commun., 23, 591-593 (1997) https://doi.org/10.1006/bbrc.1997.7016
- Heijnen, C. G., Haenen, G. R., van Acker, F. A., van der Vijgh, W. J., and Bast, A., Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. Toxicol. In Vitro, 15, 3-6 (2001) https://doi.org/10.1016/S0887-2333(00)00053-9
- Hertog, M. G., Kromhout, D., Aravanis, C., Blackburn, H., Buzina, R., Fidanza, F., Giampaoli, S., Jansen, A., Menotti, A., and Nedeljkovic, S., Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med., 155, 381-386 (1995) https://doi.org/10.1001/archinte.155.4.381
- Huie, R. and Padmaja, S., The reaction of NO and superoxide. Free Radic. Res. Commun., 18, 195-199 (1993) https://doi.org/10.3109/10715769309145868
- Jung, H. A., Kim, A. R., Chung, H. Y., and Choi, J. S., In vitro antioxidant activity of some selected Prunus species in Korea. Arch. Pharm. Res., 25, 865-872 (2002) https://doi.org/10.1007/BF02977006
- Kim, H. J., Yu, B. P., and Chung, H.Y., Molecular exploration of age-related NF-kappaB/IKK downregulation by calorie restriction in rat kidney. Free Radic. Biol. Med., 32, 991-1005 (2002) https://doi.org/10.1016/S0891-5849(02)00798-0
- Kim, H. K., Cheon, B. S., Kim, Y. H., Kim, S. Y., and Kim, H. P., Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem. Pharmacol., 58, 759-765 (1999) https://doi.org/10.1016/S0006-2952(99)00160-4
- Kimura, S., Watanabe, K., Yajiri, Y., Motegi, T., Masuya, Y., Shibuki, K., Uchiyama, S., Homma, T., and Takahashi, H., Cerebrospinal fluid nitric oxide metabolites in painful diseases. Neuro. Report, 10, 275-279 (1999) https://doi.org/10.1097/00001756-199902050-00013
- Klotz, L. O. and Sies, H., Defenses against peroxynitrite: selenocompounds and flavonoids. Toxicol. Lett., 140-141, 125-132 (2003) https://doi.org/10.1016/S0378-4274(02)00511-8
- Kooy, N., Royall, J., Ischiropoulos, H., and Beckman, J., Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic. Res. Commun.,16, 149-156 (1994)
- Kroncke, K., Fehsel, K., and Kolb-Bachofen, V., Inducible nitric oxide synthase in human disease. Clin. Exp. Immunol., 113, 147-156 (1998) https://doi.org/10.1046/j.1365-2249.1998.00648.x
- Le Marchand, L., Cancer preventive effects of flavonoids-a review. Biomed. Pharmacother., 56, 296-301 (2002) https://doi.org/10.1016/S0753-3322(02)00186-5
- Liang, Y., Huang, Y., Tsai, S., Lin-Shiau, S., Chwn, C., and Lin, J., Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis, 20, 1945-1952 (1999) https://doi.org/10.1093/carcin/20.10.1945
- Lopez-Lazaro, M., Flavonoids as anticancer agents: structureactivity relationship study. Curr. Med. Chem. Anti-Canc., Agents 2, 691-714 (2002) https://doi.org/10.2174/1568011023353714
- Mathy-Hartert, M., Deby-Dupont, G. P., Reginster, J. Y., Ayache, N., Pujol, J. P., and Henrotin, Y. E., Regulation by reactive oxygen species of interleukin-1beta, nitric oxide and prostaglandin E(2) production by human chondrocytes. Osteoarthritis Cartilage, 10, 547-555 (2002) https://doi.org/10.1053/joca.2002.0789
- Matsuda, H., Morikawa, T., Ando, S., Toguchida, I., and Yoshikawa, M., Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. Bioorg. Med. Chem., 11, 1995-2000 (2003) https://doi.org/10.1016/S0968-0896(03)00067-1
- Mavis, R. and Stellwagen, E., Purification and subunit structure of glutathione reductase from bakers yeast. J. Biol. Chem., 243, 809-814 (1968)
- Middleton, E. Jr., Kandaswami, C., and Theoharides, T. C., The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev., 52, 673-751 (2000)
- Nagata, N., Momose, K., and Ishida, Y., Inhibitory effects of catecholamines and anti-oxidants on the fluorescence reaction of 4,5-diaminofluorescein, DAF-2, a novel indicator of nitric oxide. J. Biochem., 125, 658-661 (1999) https://doi.org/10.1093/oxfordjournals.jbchem.a022333
- Ohshima, H., Yoshie, Y., Auriol, S., and Gilibert, I., Antioxidant and pro-oxidant actions of flavonoids: effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion. Free Radic. Biol. Med., 25, 1057-1065 (1998) https://doi.org/10.1016/S0891-5849(98)00141-5
- Olszanecki, R., Gebska, A., Kozlovski, V. I., and Gryglewski, R. J., Flavonoids and nitric oxide synthase. J. Physiol. Pharmacol., 53, 571-584 (2002)
- Rice-Evans, C. A., Miller, N. J., and Paganga, G., Structureantioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med., 20, 933-956 (1996) https://doi.org/10.1016/0891-5849(95)02227-9
- Shen, S. C., Lee, W. R., Lin, H. Y., Huang, H. C., Ko, C. H., Yang, L. L., and Chen, Y. C., In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharideinduced nitric oxide and prostaglandin E(2) production. Eur. J. Pharmacol., 446, 187-194 (2002) https://doi.org/10.1016/S0014-2999(02)01792-2
- Stuehr, D., Mammalian nitric oxide synthase. Biochem. Biophys. Acta, 1441, 217-230 (1999)
- Tada, H., Shiho, O., Kuroshima, K., Koyama, M., and Tsukamoto, K., An improved colorimetric assay for interleukin 2. J. Immunol. Methods, 93, 157-165 (1986) https://doi.org/10.1016/0022-1759(86)90183-3
- Wheeler, A. P. and Bernard, G. R., Treating patients with severe sepsis. N. Engl. J. Med., 340, 207-214 (1999) https://doi.org/10.1056/NEJM199901213400307