Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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A Family-Based and Case-Control Association Study of the Serotonin 1B Receptor Gene Polymorphism in Korean Attention Deficit Hyperactivity Disorder

한국인 주의력결핍 과잉행동장애와 세로토닌 1B 수용체 유전자 다형성의 관련성:가족기반 연구 및 환자-대조군 연구

  • Park, Tae Won (Research Institute of Clinical Medicine, Chonbuk National University) ;
  • Kim, Boong Nyun (Division of Child & Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University) ;
  • Im, Myung-Ho (Department of Psychiatry, College of Medicine, Dankook University) ;
  • Yoo, Hee Jeong (Department of Psychiatry, College of Medicine, Gyeongsang National University) ;
  • Kang, Daehee (Department of Preventive Medicine, College of Medicine, Seoul National University) ;
  • Chung, Young-Chul (Department of Psychiatry, College of Medicine, Chonbuk National University)
  • 박태원 (전북대학교 임상의학연구소) ;
  • 김붕년 (서울대학교 의과대학 정신과학교실 소아청소년 분과) ;
  • 임명호 (단국대학교 의과대학 정신과학교실) ;
  • 유희정 (경상대학교 의과대학 정신과학교실) ;
  • 강대희 (서울대학교 의과대학 예방의학교실) ;
  • 정영철 (전북대학교 의과대학 정신과학교실)
  • Published : 2004.11.30
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Abstract

Objective:Attention deficit hyperactivity disorder(ADHD) is the most common childhood psychiatric disorder, affecting 3-5% of school-aged children. Although the biological basis of ADHD is unknown, family studies provide strong evidence that ADHD has a genetic basis. Recent genetic studies have suggested associations between ADHD and serotonin 1B(5HT1B) receptor gene G861C polymorphism. The aim of this study is to test for the association between ADHD and 5HT1B receptor gene G861C polymorphism in Korean population. Method:We processed DNA extraction and genotyping. 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test(TDT) and haplotype-based haplotype relative risk (HHRR). And the ADHD children were compared with 212 age and gender matched normal controls. Results:There was no statistical difference of distributions between ADHD cases and controls. We did not observe any preferential transmission of alleles of 5HT1B receptor gene G861C polymorphism in ADHD. Conclusions:Though there is the possibility of failing to detect small genetic effects, our results show no evidence of an association between ADHD and 5HT1B receptor gene G861C polymorphism in the Korean population and indicate that it is unlikely that the 5HT1B receptor is implicated in the susceptibility to ADHD.

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