Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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An Association Study of the 5-HTTLPR and COMT Genes Polymorphisms and Personality Traits

5-HTTLPR과 COMT 유전자 다형성과 성격 특성에 대한 연합연구

  • Ha, Jee-Hyun (Yong-In Psychiatric Research Institute) ;
  • Ham, Byung-Joo (Department of Neuropsychiatry, College of Medicine, Hallym University) ;
  • Ryu, Sung-Gon (Department of Neuropsychiatry, College of Medicine, Hallym University) ;
  • Hwang, Tae-Yeon (Yong-In Psychiatric Research Institute) ;
  • Lee, Jong-Gook (Yong-In Psychiatric Research Institute) ;
  • Lee, Yu-Sang (Yong-In Psychiatric Research Institute) ;
  • Lee, Jung-Sik (Yong-In Psychiatric Research Institute) ;
  • Kang, Dae Yeob (Yong-In Psychiatric Research Institute) ;
  • Choi, Ihn-Geun (Department of Neuropsychiatry, College of Medicine, Hallym University) ;
  • Lee, Min Soo (Department of Psychiatry, College of Medicine, Korea University)
  • 하지현 (용인정신의학연구소, 용인정신병원) ;
  • 함병주 (한림대학교 의과대학 신경정신과학교실) ;
  • 류성곤 (한림대학교 의과대학 신경정신과학교실) ;
  • 황태연 (용인정신의학연구소, 용인정신병원) ;
  • 이종국 (용인정신의학연구소, 용인정신병원) ;
  • 이유상 (용인정신의학연구소, 용인정신병원) ;
  • 이정식 (용인정신의학연구소, 용인정신병원) ;
  • 강대엽 (용인정신의학연구소, 용인정신병원) ;
  • 최인근 (한림대학교 의과대학 신경정신과학교실) ;
  • 이민수 (고려대학교 의과대학 정신과학교실)
  • Published : 2004.11.30
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Abstract

Background:Serotonin transporter gene-linked polymorphism region(5-HTTLPR) and catechol-O-methyltransferase( COMT) genes are thought to be important factors in some personality traits and the etiology of anxiety disorder. The goal of this study was to determine the role of these genes in personality traits. Method:The participants included 116 healthy adults with no history of psychiatric disorders and other physical illness for the last 6 months. All participants were tested by Temperament and Character Inventory(TCI). The 5-HTTLPR, COMT val158met gene polymorphisms were analyzed with PCR(Polymerase Chain Reaction). Differences on TCI dimensions and sub-scales among groups were examined with t-test and ANOVA. Result:There were possible relationships of the 5-HTTLPR with self-transcendence(P=0.050) and COMT val158met polymorphism with cooperativeness(P=0.053). Conclusion:We found associations between 5-HTTLPR, COMT polymorphisms and the some TCI character dimensions. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.

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