A Case of Primary Pulmonary Plasmacytoma Presenting as Endobronchial Mass

기관지내 종괴로 발현된 일차성 폐 형질 세포종 1예

  • Suh, Soon Yong (Department of Internal Medicine, College of Medicine Korea University) ;
  • Ko, Gang Jee (Department of Internal Medicine, College of Medicine Korea University) ;
  • Kim, Chung Ho (Department of Internal Medicine, College of Medicine Korea University) ;
  • Kim, Youn Ho (Department of Internal Medicine, College of Medicine Korea University) ;
  • Lee, Sung Yong (Department of Internal Medicine, College of Medicine Korea University) ;
  • Lee, Sang Yeub (Department of Internal Medicine, College of Medicine Korea University) ;
  • Kim, Je Hyeong (Department of Internal Medicine, College of Medicine Korea University) ;
  • Shin, Chol (Department of Internal Medicine, College of Medicine Korea University) ;
  • Shim, Jae Jeong (Department of Internal Medicine, College of Medicine Korea University) ;
  • In, Kwang Ho (Department of Internal Medicine, College of Medicine Korea University) ;
  • Kang, Kyung Ho (Department of Internal Medicine, College of Medicine Korea University) ;
  • Yoo, Se Hwa (Department of Internal Medicine, College of Medicine Korea University)
  • 서순용 (고려대학교 의과대학 내과학교실) ;
  • 고강지 (고려대학교 의과대학 내과학교실) ;
  • 김청호 (고려대학교 의과대학 내과학교실) ;
  • 김연호 (고려대학교 의과대학 내과학교실) ;
  • 이승룡 (고려대학교 의과대학 내과학교실) ;
  • 이상엽 (고려대학교 의과대학 내과학교실) ;
  • 김제형 (고려대학교 의과대학 내과학교실) ;
  • 신철 (고려대학교 의과대학 내과학교실) ;
  • 심재정 (고려대학교 의과대학 내과학교실) ;
  • 인광호 (고려대학교 의과대학 내과학교실) ;
  • 강경호 (고려대학교 의과대학 내과학교실) ;
  • 유세화 (고려대학교 의과대학 내과학교실)
  • Published : 20040000

Abstract

Extramedullary plasmacytoma(EMP) comprises 5% of all plasma cell neoplasms and commonly occurs in the upper airway or digestive tract. However, it rarely develops in the lungs. We present a case of primary pulmonary plasmacyotma in a 45 year old man, who presented as an endobronchial mass with a pleural effusion, but without evidence of multiple myeloma. The treatment options for EMP include surgery, surgery and radiotherapy, surgery and chemotherapy or chemotherapy alone. Surgery and radiation therapy appeared to be equally effective forms of treatment. The local recurrence rate was reported to be 30%, with 48% progressing to multiple myeloma, and median survival was reported to be 63-101 months. Our patient was initially treated with melphalan and prednisolone. However the disease progressed, and radiotherapy was combined with chemotherapy. In addition, the chemotherapy regimen was also changed to thalidomide and dexamethasone. The patient did not respond to this treatment regimen and finally died.

저자들은 기관지내 종괴로 발현된 일차성 폐 형질세포종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. 김유미, 김승철. 원발성 폐 형질세포종: 1예보고. 대한방사선의학회지 1999;40:887-9
  2. Hayes-lattin B, Blanke CD, Deloughery TG. Pulmonary and intracerebral Plasmacytomas in a patient without multiple myeloma; A case report. American journal of hematology 2003;73:131-4
  3. Wise JN, Schaefer RF, Read RC. Primary pulmonary plasmacytoma: A case report. Chest 2001;120;1405-7
  4. Joseph G, Pandit M, Korfhage L. Primary pulmonary plasmacytoma. cancer 1993;71:721-4
  5. Wasserman T. Diagnosis and management of plasmacytoma. Oncology 1987;1:37-40
  6. Wang J, Pandha HS, Treleaven J, Powles R, Metastatic Extramedullary Plasmacytoma of the Lung. Leukemia and lymphoma 1999;35(3-4):423-5
  7. Horuchi T, Hirokawa M, Oyama Y, Kitabayashi A, Satoh K, Shindoh T, et al. Diffuse pulmonary infiltrates as a Roentgenographic Manifestation of Primary Pulmonary Plasmacytoma. The American journal of medicine 1998;105:72-4
  8. Piard F, Yaziji N, Jarry O, Assem M, Martin L, Bernard A, et al Solitary plasmacytoma of the lung with light chain extracellular deposits: a case report and review of the literature. Histopathology 1998;32:356-61
  9. Wiltshaw E. The natural history of extrame dullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine 1976;55:217-38
  10. Brackett E, Myers JR, Sherman CB. Laser treatment of endobronchial extramedullary plasmacytoma. Chest 1994;106:1276-7