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자생식물 열수추출액의 항균효능 검색

Screening of Antibacterial Activity from Hot Water Extracts of Indigenous Plants

  • 민상기 (부산광역시보건환경연구원) ;
  • 박연경 (부산광역시보건환경연구원) ;
  • 박지연 (부산광역시보건환경연구원) ;
  • 진성현 (부산광역시보건환경연구원) ;
  • 김규원 (서울대학교 약학대학)
  • Min Sang-Kee (Division of Microbiology, Busan Institute of Health and Environment) ;
  • Park Yeong-Kyung (Division of Microbiology, Busan Institute of Health and Environment) ;
  • Park Ji-Hyun (Division of Microbiology, Busan Institute of Health and Environment) ;
  • Jin Sung-Hyun (Division of Microbiology, Busan Institute of Health and Environment) ;
  • Kim Kyu-Won (College of Pharmacy, Seoul National University)
  • 발행 : 2004.12.01

초록

병원성세균에 대한 자생식물 열수 추출물 141종의 항균효능을 검색하였다. 실험대상 식물은 생체 채집하여 건조 후 열수 추출하여 시료화 하였으며 디스크 확산법으로 항균력을 측정하였고 시험 대상 균주로는 그람양성균 7주 및 그람음성균 12주를 사용하였다. 그 결과 그람양성군 1주 이상에 항균효능을 보이는 식물은 55종이었으며 특히 달맞이꽃(꽃), 석류(과피), 굴참나무(도토리), 사방소리 나무(미성숙과), 물오리나무(미성숙과), 칡(꽃), 이질풀(지상부), 배롱나무(꽃)은 6주 이상에서 광범위 항균 스펙트럼를 보였다. 그람음성균 1주 이상에 항균효능을 보이는 식물은 45종이었으며 달맞이 꽃(꽃), 석류(과피), 굴참나무(도토리), 오미자(성숙과), 사방오리나무(미성숙과), 물오리나무(미성숙과), 목련(미성숙과)은 8주 이상에서 광범위 항균스펙트럼을 보였다. 본 연구결과 식용 가능하며 항균효능을 보인 달맞이꽃 (꽃), 석류(과피, 꽃), 굴참나무(도토리), 오미자(성숙과)의 열수 조추출물은 식품 보존제 및 가축 식이사료 등에 첨가하여 병원균 감염예방 등의 항균효과를 기대할 수 있을 것으로 사료된다.

Hot water extracts of 141 indigenous plants were screened for antibacterial activity against 7 Gram (+) and 12 Gram (-) bacteria by agar diffusion method. Of the 141 plants tested, 55 showed antibacterial activity against one or more species of Gram (+) bacteria and especially extracts of Oenothera stricta Ledebour (Onagraceae), Quercus variabilis Blume (Fagaceae), Alnus firma (Betulaceae), Geranium thunbergii (Geraniaceae), Lagerstroemia indica (Lythraceae) showed broad spectrum antibacterial activity on over 6 strains. Of the 141 plants tested, 45 showed antibacterial activity against one or more species of Gram (-) bacteria and especially extracts of Oenothera stricta Ledebour (Onagraceae), Punica granatum (Lythraceae), Quercus variabilis Blume (Fagaceae), Schizandra chinensis Baillon (Magnoliaceae), Alnus firma (Betulaceae), Alnus hirsuta (Betulaceae), Magnolia kobus (Magnoliaceae) showed broad spectrum antibacterial activity on over 8 strains. The most active antibacterial plants were Oenothera stricta Ledebour (Onagraceae), Punica granatum (Lythraceae), Quercus variabilis Blume (Fagaceae), Schizandra chinensis Baillon (Magnoliaceae) which are edible as permitted by Korea Food & Drug Adminstration. With in-depth research, the hot water extracts of these plants can be applied as food preservatives and alternatives of antimicrobials for livestock feeds.

키워드

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