대한두경부종양학회지 (Korean Journal of Head & Neck Oncology)

  • 제20권1호
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  • Pages.13-18
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  • 2004
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  • 1229-5183(pISSN)
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  • 2586-2553(eISSN)
대한두경부종양학회 (The Korean Society for Head and Neck Oncology)
권호 표지

두경부 편평 세포암의 원발 병소와 전이 경부 림프절에서 Matrix Metalloproteinase-9와 Basic Fibroblast Growth Factor의 발현

Expression of Matrix Metalloproteinase-9 and Fibroblast Growth Factor in Squamous Cell Carcinoma of the Head and Neck and Metastaric Cervical Lymph Node

  • 노영수 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 황준식 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김진 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김진환 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 조성진 (한림대학교 의과대학 병리학교실) ;
  • 신형식 (한림대학교 의과대학 병리학교실)
  • Rho Young-Soo (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Hwang Joon-Sik (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Kim Jin (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Kim Jin-Hwan (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Cho Sung-Jin (Department of Pathology, Hallym University College of Medicine) ;
  • Shin Hyung-Sik (Department of Pathology, Hallym University College of Medicine)
  • 발행 : 2004.05.01
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초록

Objectives: Cancer lethality is usually the result of local invasion and metastasis of neoplastic cell from the primary tumor. Because of their ability to degrade extracellular matrix components, matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) have been implicated in the breakdown of basement membrane and underlying stroma, thereby facilitating tumor growth and invasion. It has been well established that MMPs and bFGF expression correlate with cervical lymph node metastasis, but studies on expression in the metastatic cervical lymph node itself are not enough. We have analyzed matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) in squamous cell carcinoma of the head and neck and metastatic cervical lymph node, and evaluated their relationship and clinicophathologic significance. Material and Methods: 20 cases of squamous cell carcinoma of the head and neck were entered on the study of immunohistochemical stains for MMP-9 and bFGF in the obtained tissue from primary tumor and metastatic cervical lymph node. We analyzed the relationship between MMP-9, bFGF expression of the primary tumor and metastatic node with age, sex, T-stage, N-stage, histologic grade, pathologic stage and disease free survival. Results: Expression of MMP-9 and bFGF in cancer cell and metastatic lymph node was higher than that in normal cell and lymph node. According to histologic differentiation, expression of MMP-9 of the metastatic cervical lymph node was higher than primary tumor. Considering to other clinicopathologic factor, no statistical significance was seen in MMP-9 and bFGF. Conclusion: We found that expression of MMP-9 is higher in the metastatic lymph node than primary tumor in the poorly differentiated squamous cell carcinoma. But we don't find out the statistical significance in relation between bFGF and clinical factors. So we guess that some different mechanism of MMP-9 and bFGF in Head & Neck squamous cell carcinoma exist. Further studies will be necessary to establish their pathogenesis in the Head and Neck cancer.

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참고문헌

  1. Mibnatti P, Rifkin DB : Biology and Biochemistry of proteinase in tumor invasion. Physiol Rev. 1993 ; 73 : 161-187 https://doi.org/10.1152/physrev.1993.73.1.161
  2. Liotta LA : Tumor invasion and metastasis : role ofthe extracelluar matrix cancer research. 1986 ; 46 : 1-7
  3. Fidler IJ, Radinsky R : Genetic control of cancer metastasis. J Natl Cancer Inst. 1990 ; 82 : 166-168 https://doi.org/10.1093/jnci/82.3.166
  4. Kurahara S, Shinohara M, Ikebe T, et al : Expression of MMPs, MT-MMP and TIMPs in squamous cell carcinoma of the oral cavity : correlation with tumor invasion and metastastasis. Head and Neck. 1999 ; 21 : 627-638 https://doi.org/10.1002/(SICI)1097-0347(199910)21:7<627::AID-HED7>3.0.CO;2-2
  5. Kahari VM, Saarialho-Kere U : Matrix metalloproteinase in skin. Exp Dermatol. 1997 ; 6 : 199-213 https://doi.org/10.1111/j.1600-0625.1997.tb00164.x
  6. Welkoborski HJ, Mann WJ, Gluckman JL, Freue JE : Comparison of quantitative DNA measurements and cytomorphology in squamous cell carcinomas of upper aerodigestive tract with and without lymph node metastases, Ann Otol Rhinol Laryngol. 1993 ; 102 : 52-57
  7. Kawamata H, Nakashiro K, Uchida D, Harada K, Yoshida H, Sato M : Pssible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to invasion of newly established human oral squamaus cancer cell line. Int J Cancer. 1997 ; 70 : 120-127 https://doi.org/10.1002/(SICI)1097-0215(19970106)70:1<120::AID-IJC18>3.0.CO;2-P
  8. Riedel F, Gotte K, Schwalb J, Hormann K : Serum levels of matrix metalloproteinase-2 and -9 in patients with hean and neck squamous cell carcinoma. Anticancer Res. 2000 Sep-Oct ; 20 (5A) : 3045-3049
  9. O-Charoemat P, Rhys-Evans PH, Eccles SA : Expression of matrix metalloproteinase and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma ofthe head and neck. Arch Otolaryngol Head Neck Surg. 2001 ; 127 : 813-820
  10. Alvarez OA, Carmichael DF, De Clerck YA : Inhibition of collagenolytic activity and metastasis oftumor cells by a recombinant human tissue inhibitor ofmetalloproteinase. J Natl Cancer Inst. 1990 ; 82 : 589-595 https://doi.org/10.1093/jnci/82.7.589
  11. Dellacono FR, Spiro J, Eism R, kreutzer D : Ezpression of basic fibroblast growth factor and its receptor by head and Neck Squamous cell carcinoma tumor and vascular endothelial cells. Am J Surg. 1997 ; 174 : 540-544 https://doi.org/10.1016/S0002-9610(97)00169-4
  12. Hori A, Sasada R, Matsutani E, et al : Supression od solid tumor growth by immuno-neurtalizing monoclonal antibody against human basic growth factor. Cancer Res. 1991 ; 51 : 6180-6184
  13. Burian M, Quint C, Neuchrist C : Angiogenic factor in Laryngeal carcinoma : Do they have prognostic relevance? Acta Otolaryngol. 1999 ; 119 : 289-292