References
- Rao KV, Detrisac CJ, Steele VE, Hawk ET, Kelloff GJ, McCormick DL. Differential acti-vity of aspirin, ketoprofen and sulindac as cancer chemopreventive agents in the mouse urinary bladder. Carcinogenesis 1996;17:1435-8
- Smalley WE, DuBois RN. Colorectal cancer and nonsteroidal anti-inflammatory drugs. Adv Pharmacol 1997;39:1-20
- Shiff SJ, Rigas B. Nonsteroidal anti-inflam-matory drugs and colorectal cancer: evolving concepts of their chemopreventive actions Gastroenterology 1997;113:1992-8
- Giardiello FM, Spannhake EW, DuBois RN, Hylind LM, Robinson CR, Hubbard WC, et al. Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. Dig Dis Sci 1998;43:311-6
- Giardiello FM, Hamilton SR, Krush AJ, Piantadosi S, Hylind LM, Celano P, et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous poly-posis. N Engl J Med 1993;328:1313-6
- DuBois RN, Radhika A, Reddy BS, Entingh AJ. Increased cyclo-oxygenase-2 levels in carcinogen-induced rat colonic tumors. Ga-stroenterology 1996;110:1259-62
- Piazza GA, Rahm AL, Krutzsch M, Sperl G, Paranka NS, Gross PH, et al. Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Cancer Res 1995;55:3110-6
- Han EK, Arber N, Yamamoto H, Lim JT, Delohery T, Pamukcu R, et al. Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines. Breast Cancer Res Treat 1998;48:195-203
- Soriano AF, Helfrich B, Chan DC, Heasley LE, Bunn PA Jr, Chou TC. Synergistic ef-fects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. Cancer Res 1999;59:6178-84
- Chan DC, Earle KA, Zhao TL, Helfrich B, Zeng C, Baron A, et al. Exisulind in com bination with docetaxel inhibits growth and metastasis of human lung cancer and pro longs survival in athymic nude rats with orthotopic lung tumors. Clin Cancer Res 2002;8:904-12
- Hial V, De Mello MC, Horakova Z, Beaven MA. Antiproliferative activity of anti-inflam matory drugs in two mammalian cell culture lines. J Pharmacol Exp Ther 1977;202:446-54
- Waddell WR, Gemer RE. Indomethacin and ascorbate inhibit desmoid tumors. J Surg Oncol 1980;15:85-90
- Waddell WR, Loughry R. Sulindac for polyposis of the colon. J Surg Oncol 1983; 24:83-7
- Elder DJ, Halton DE, Hague A, Paraskeva C. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxy-genase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: Independence from COX-2 protein expression. Clin Cancer Res 1997;3:1679-83
- Lim JT, Piazza GA, Han EK, Delohery TM, Li H, Finn TS, et al. Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines. Biochem Pharmacol 1999;58:1097-107
- Keller JJ, Offerhaus GJ, Polak M, Goodman SN, Zahurak ML, Hylind LM, et al. Rectal epithelial apoptosis in familial adenomatous polyposis patients treated with sulindac. Gut 1999;45:822-8
- Wu YL, Sun B, Zhang XJ, Wang SN, He HY, Qiao MM, et al. Growth inhibition and apoptosis induction of sulindac on human gastric cancer cells. World J Gastroenterol, 2001;7:796-800
- Hanif R, Pittas A, Feng Y, Koutsos MI, Qiao L, Staiano-Coico L, et al. Effects of non-steroidal anti-inflammatory drugs on prolifer-ation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem Pharmacol 1996;52:237-45
- Piazza GA, Rahm AK, Finn TS, Fryer BH, Li H, Stoumen AL, et al. Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxy genase inhibition, cell cycle arrest, and p53 induction. Cancer Res 1997;57:2452-9
- Liu JJ, Wang JY, Hertervig E, Nilsson A, Duan RD. Sulindac induces apoptosis, inhibits proliferation and activates caspase-3 in Hep G2 cells. Anticancer Res 2002;22:263-6
- Skopinska-Rozewska E, Piazza GA, Sommer E, Pamukcu R, Barcz E, Filewska M, et al. Inhibition of angiogenesis by sulindac and its sulfone metabolite(FGN-1): a potential me-chanism for their antineoplastic properties. Int J Tissue React 1998;20:85-9
- Thompson WJ, Pamulku R, Liu L, Li H, Ahnen D, Speri G, et al. Exisulind induced apoptosis in cultured colonic tumor cells involves inhibition of cyclic GMP phospho-diesterase. Proc Am Assoc Cancer Res 1999;40:4-9