Pediatric Gastroenterology, Hepatology & Nutrition
- Volume 7 Issue 1
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- Pages.92-97
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- 2004
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- 2234-8646(pISSN)
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- 2234-8840(eISSN)
Successful Treatment with Partial Splenic Embolization in a Case of Post-transplantations Lymphoproliferative Disease with Persistent Hypersplenism
림프세포증식성 질환에서 효과를 보인 부분적 비동맥 색전술 1례
- Kim, Mi Jin (Department of Pediatrics, College of Medicine, Chosun University) ;
- Rho, Young Il (Department of Pediatrics, College of Medicine, Chosun University) ;
- Yang, Eun Seok (Department of Pediatrics, College of Medicine, Chosun University) ;
- Moon, Kyung Rye (Department of Pediatrics, College of Medicine, Chosun University)
- 김미진 (조선대학교 의과대학 소아과학교실) ;
- 노영일 (조선대학교 의과대학 소아과학교실) ;
- 양은석 (조선대학교 의과대학 소아과학교실) ;
- 문경래 (조선대학교 의과대학 소아과학교실)
- Received : 2004.02.28
- Accepted : 2004.03.19
- Published : 2004.03.01
Abstract
Posttranplantations lymphoproliferative disease (PTLD) is a common and life-threatening complication for soid organ transplantation associated with the use of chronic immunosuppression and Epstein-Barr virus. There is no standardized treatment algorithm, but numerous management strategies are vaiable. Partial splenic embolization (PSE) had been demonstrated to be an effetive alternatie to splenectomy for patients hypersplenism and portal hypertension. PSE has the advantages of non-invasive intervention and resolution of the complications of hypersplenism. We report the effect of the PSE in a 6-year old male liver transplantation recepient with PTLD who has undergone persistent hypersplenism post-transplant. We reduced immunosuppression agent, started antiviral agent. We started with interferon and IV globulin one month after admission. Hepatosplenomegaly and cervical lymphadenopathy were improved. But fever was not subside. We selectively embolized the lower pole of the spleen to achieve a 50~60% reduction in flow as determined by angiography. After embolization, fever subside and peripheral blood findings were improved. Follow up abdominal CT revealed reduced volume of spleen due to ischemic change and there was no multiple enlarged mesenteric lymphnode compared to preembolization state. We thick that PSE is a safe an effetive treatment modality of PTLD with persistent hypersplenism in patients twho failed to medical treatment.
저자들은 간 이식 후 지속적 비기능 항진에 발생된 내과적 치료에 반응하지 않는 림프세포증식성질환의 6세된 남아에서 부분적 비동맥 색전술을 치료의 한 방법으로 선택하였다. 비기능항진의 억제 효과로 면역력 증강을 통해 혈액학적 호전을 유도하고자 하였으며 치료 후 PTLD의 호전을 보인 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.