Journal of Acupuncture Research
- Volume 21 Issue 2
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- Pages.155-166
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- 2004
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
Beneficial Effect of Semen Plantaginis Herbal-Acupuncture on Cisplatin-Induced Acute Renal Failure in Rabbits
차전자약침(車前子藥鍼)이 Cisplatin에 의해 유발된 급성 신부전에 미치는 영향
- Park, Chun-ha (Department of Acupuncture & Moxibustion, College of Oriental Medicine Dong-shin University) ;
- Chae, Woo-seok (Department of Acupuncture & Moxibustion, College of Oriental Medicine Dong-shin University) ;
- Yun, Yeo-choong (Department of Acupuncture & Moxibustion, College of Oriental Medicine Dong-shin University)
- Received : 2004.03.16
- Accepted : 2004.03.22
- Published : 2004.04.20
Abstract
Objective : The present study was carried out to determine if Semen Plantaginis Herbal-Acupuncture exerts beneficial effect against the cisplatin-induced acute renal failure in rabbits. Method : Semen Plantaginis was selected in the basis of invigorating kidney-QI which can eliminate pathogens. The oxidative stability determined by the Rancimat technique showed higher antioxidative index when compared with control. Rabbits were treated with Semen Plantaginis Herbal-Acupuncture on Shin-shu point for 3 days, followed by cisplatin injection(5mg/kg body weight). Results : Cisplatin injection caused an increase in serum creatinine level, which was accompanied by a reduction in GFR. The fractional excretion of