Journal of Acupuncture Research

  • 제21권3호
  • /
  • Pages.145-167
  • /
  • 2004
  • /
  • 2586-288X(pISSN)
  • /
  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
권호 표지

환도혈(環跳穴) 오공약침(五蚣藥鍼) 자극(刺戟)이 백서(白鼠)의 신경병리성(神經病理性) 통증(痛症) 억제(抑制)에 미치는 영향(影響)

Inhibitory Effect of Scolopendrid Aqua-Acupuncture Injected at Hwando(GB30) on Neuropathic Pain in Rats

  • 김성남 (원광대학교 부속한방병원 침구학교실) ;
  • 김성철 (원광대학교 부속한방병원 침구학교실) ;
  • 최회강 (원광대학교 부속한방병원 침구학교실) ;
  • 소기숙 (원광대학교 부속한방병원 침구학교실) ;
  • 임정아 (원광대학교 부속한방병원 침구학교실) ;
  • 황우준 (원광대학교 부속한방병원 침구학교실) ;
  • 문형철 (원광대학교 부속한방병원 침구학교실) ;
  • 최성용 (원광대학교 부속한방병원 침구학교실) ;
  • 이상관 (원광대학교 부속한방병원 내과학교실) ;
  • 나창수 (동신대학교 한의과대학 침구학교실)
  • Kim, Sung-nam (Department of Acupuncture and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Kim, Sung-chul (Department of Acupuncture and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Choi, Hoi-kang (Department of Acupuncture and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • So, Ki-suk (Department of Acupuncture and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Lim, Jeong-a (Department of Acupuncture and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Hwang, Woo-jun (Department of Acupuncture and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Moon, Hyung-cheol (Department of Acupuncture and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Choi, Sung-yong (Department of Acupuncture and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Lee, Sang-kwan (Department of Internal Medicine, Oriental Medical Hospital, Won-Kwang University) ;
  • Na, Chang-su (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dong-Shin University)
  • 투고 : 2004.04.23
  • 심사 : 2004.05.15
  • 발행 : 2004.06.20
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초록

Objective : Neuropathic pain can be caused by a partial peripheral nerve injury. This kind of pain is usually accompanied by spontaneous burning pain, allodynia and hyperalgesia. It is not clear that scolopendrid aqua-acupuncture can control neuropathic pain effectively. The purpose of this study is to examine if scolopendrid aqua-acupuncture may be effective to the neuropathic pain (mechanical allodynia, cold allodynia) in a rat model of neuropathic pain. Methods : To produce the model of neuropathic pain, under isoflurane 2.5% anesthesia, tibial nerve and sural nerve was resected. After the neuropathic surgery, the author examined if the animals exhibited the behavioral signs of allodynia. The allodynia was assessed by stimulating the medial malleolus with von Frey filament and acetone. Three weeks after the neuropathic surgery, scolopendrid aqua-acupuncture was injected at Hwando(GB30) one time a day for one week. After that the author examined the withdrawl response of neuropathic rats' legs by von Frey filament and acetone stimulation. And also the author examined c-fos in the midbrain central gray of neuropathic rats and the change of WBC count in the blood of neuropathic rats. Results & Conclusion : 1. The scolopendrid aqua-acupuncture injected at Hwando(GB30) decreased the withdrawl response of mechanical allodynia in SHA-1, SHA-2 and SAH-3 group as compared with control group. 2. The scolopendrid aqua-acupuncture injected at Hwando(GB30) decreased the withdrawl response of chemical allodynia(cold allodynia) in SHA-1, SHA-2 and SAH-3 group as compared with control group. 3. The scolopendrid aqua-acupuncture injected at Hwando(GB30) showed the significant difference between sham group and control group(p=0.01), sham and SHA-3 group(p=0.026), control group and SHA-1 group(p=0.01), control group and SHA-2 group(p=0.024) in the c-fos expression. 4. The scolopendrid aqua-acupuncture injected at Hwando(GB30) showed the significant difference between sham group and SHA-3 group(p=0.010), control group and SHA-3 group(p=0.006) in the WBC count.

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