Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Effect of Anti-Cancer and Immune Response Improvement of ELP(Ecliptae Herba) Herbal-Acupuncture into Chung-wan(CV12)

백서(白鼠)의 B16-F10 Melanoma에 대한 한련초약침(旱蓮草藥鍼)의 항암(抗癌) 및 면역증강효과(免疫增强效果)

  • Park, Jung-hyeun (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dae-Jeon University) ;
  • Kim, Young-il (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dae-Jeon University) ;
  • Hong, Kwon-eui (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dae-Jeon University) ;
  • Yim, Yun-kyoung (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dae-Jeon University) ;
  • Lee, Hyun (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dae-Jeon University) ;
  • Lee, Byung-ryul (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dae-Jeon University)
  • 박정현 (대전대학교 한의과대학 침구학교실) ;
  • 김영일 (대전대학교 한의과대학 침구학교실) ;
  • 홍권의 (대전대학교 한의과대학 침구학교실) ;
  • 임윤경 (대전대학교 한의과대학 침구학교실) ;
  • 이현 (대전대학교 한의과대학 침구학교실) ;
  • 이병렬 (대전대학교 한의과대학 침구학교실)
  • Received : 2004.10.11
  • Accepted : 2004.11.27
  • Published : 2004.12.20
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Abstract

Objective & Methods : To study the effects of anti-cancer, anti-metastasis and immune response improvement of herbal-acupuncture with Eclipta prostrata diffusae herba infusion solution(ELP-HAS), we injected ELP-HAS into Chung-wan(CV12) of C57BL/6 mice implanted intravenously with B16-F10 melanoma. We have reached the following conclusion through the effect on the percentage of $CD25^+/CD4^+$, $CD8^+/CD3e^+$, $CD69^+/B220^+$, $NK1.1^+/CD3e^+$cells in mouse PBMCs, the effect on the pulmonary colony formation number, and the effect on MST(Median Survival Time) and ILS(Increase of Life Span) of C57BL/6 mice implanted intravenously with B16-F10 melanoma. Results : The results were obtained as follows : 1. In the experiment groups treated with ELP(Ecliptae Herba) Herbal acupuncture, the spleen cell proliferation in BALB/c mouse was significantly increased compared with control group. 2. In the experiment groups treated with ELP(Ecliptae Herba) Herbal acupuncture, the percentage of $CD25^+/CD4^+$, $CD8^+/CD3e^+$, $CD69^+/B220^+$, $NK1.1^+/CD3e^+$cells in C57BL/6 mouse PBMCs was increased compared with control group. 3. In the experiment groups treated with ELP(Ecliptae Herba) Herbal acupuncture, the pulmonary colony formation number of C57BL/6 mice implanted intravenously with B16-F10 melanoma was decreased significantly compared with control group. 4. In the experiment groups treated with ELP(Ecliptae Herba) Herbal acupuncture, MST(Median Survival Time) and ILS(Increase of Life Span) of C57BL/6 mice implanted intravenously with B16-F10 melanoma were increased significantly compared with control group. Conclusions : ELP Herbal acupuncture injection into Chung-wan(CV12) of C57BL/6 mice is considered to be effective in anti-cancer, anti-metastasis and immune response improvement.

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