Fisheries and Aquatic Sciences

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Effects of Diethyl Phthalate on Acetylcholinesterase Activity in Olive Flounder (Paralichthys olivaceus) Following Short-term Exposure

  • Jee Jung-Hoon (Institute of Fisheries Sciences, Pukyong National University) ;
  • Keum Yoo-Hwa (Department of Aquatic Life Medicine, Pukyong National University) ;
  • Kang Ju-Chan (Department of Aquatic Life Medicine, Pukyong National University)
  • Published : 2004.09.01
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Abstract

Activity of acetylcholinesterase (AChE) is well known as a biomarker of exposure to organophosphate compounds in aquatic organisms. However, the effect of diethyl phthalate (DEP), a widely used plasticizer, on the chance of AChE activity is not yet known. Olive flounder (Paralichthys olivaceus) were exposed to DEP 300 and 1,000 mg DEP/kg b.w. through three times of intraperitoneal injection and effects were assessed in AChE activity of brain, muscle, heart and eyes of the exposed fish. AChE activity in various tissues of flounder was inhibited after exposure to DEP as a concentration-dependent manner, especially in brain, muscle and heart. Among tissues examined, heart is supposed to be a major part of body which is seriously damaged by DEP exposure. It indicates that DEP induces toxic effects in various organs (brain, muscle and heart), and changes of AChE activities. Such changed activities of AChE might be a useful biomarker to assess the impacts induced by phthalate esters including DEP.

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References

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