Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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A Case of Complete Remission of Hairy Cell Leukemia by 2-Chlorodeoxyadenosine

2-Chlorodeoxyadenosine에 의해 완전관해가 유도된 모발상 세포백혈병 1예

  • Kim, Yong-Gil (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Lee, Sang-Jin (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Kim, Min-Kyung (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Lee, Kyung-Hee (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Hyun, Myung-Soo (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Cho, Hee-Sun (Department of Laboratory Medicine, College of Medicine, Yeungnam University)
  • 김용길 (영남대학교 의과대학 내과학교실) ;
  • 이상진 (영남대학교 의과대학 내과학교실) ;
  • 김민경 (영남대학교 의과대학 내과학교실) ;
  • 이경희 (영남대학교 의과대학 내과학교실) ;
  • 현명수 (영남대학교 의과대학 내과학교실) ;
  • 조희순 (영남대학교 의과대학 진단검사의학교실)
  • Published : 2004.12.30
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Abstract

Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder that is characterized by cytopenia, splenomegaly, and mononuclear cells displaying cytoplasmic projections. We experienced a case of hairy cell leukemia that developed in a 38-year-old man. He showed marked splenomegaly without palpable lymphoadenopathy. A complete blood cell count revealed leukopenia ($3300/{\mu}{\ell}$ with 63% of lymphocyte) and the peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow smear revealed abnormal lymphocytes and severe myelofibrosis. Tartrate-resistant acid phosphatase reactivity was strongly positive in the hairy cells. The immunophenotyping results of lymphoid cells were CD5(-), CD10(-), CD19(+), CD25(+), CD103(+), CD20(+), lambda(+). The patient was treated with 2-Chlorodeoxyadenosine at a daily dose of 0.1mg/Kg by a continuous intravenous infusion for 7 days. The patient achieved complete remission.

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