Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
권호 표지

Cosmetical Properties of Polysccharides from the Root Bark of Ulmus davidiana var. Japonica

유근피로부터 추출한 다당류의 화장료적 특성

  • 김영실 ((주)참존 응용연구소) ;
  • 김종헌 ((주)참존 응용연구소) ;
  • 김기호 ((주)바이오랜드 생명공학연구소)
  • Published : 2004.12.01
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Abstract

The fruit or root of Ulmus davidiana var. Japonica and its extract has traditionally been used as anti inflammatation medicines as well as a remedy of the digestive ulcer for a long time. Ulmus davidiana var. Japonica has also been used to cure palliative and diuresis, because it contains lot of mucus and tannin. In this study, we examined the moisturizing effect and anti-inflammation effect of polysaccharides extracted from Ulmus davidiana var. Japonica to investigated whether it can be used as a cosmetic ingredient or not. The polysaccharides were extracted from Ulmus davidiana var. Japonica. Then the hydrolyzed was obtained through the hydrolysis. It has been ascertained that the polysaccharides we mainly composed of rhamnose, galactose, and glucose through HPLC experiments, and it has 20,000 of the molecular weight and 89.3 dL/g of intrinsic viscosity In a moisturizing test of measuring water loss in a desiccator and moisture content by Comeometer CM820, Ulmus davidiana root extract showed a similar moisturizing effect as hyaluronic acid. And its anti-inflammation effect on carrageenin-induced edema evaluated by measuring the thickness of swelling over paw induced by carrageenin (25 uL of $2\%$ carrageenin saline injection), the $\%$ swelling over paw treated with Ulmus davidiana root extract was much less than that of paw treated with carrageenin only. The anti-inflammatory effect of Ulmus davidiana root extract was almost similar to that of ketoprofen. These results can say that Ulmus davidiana root extract can be effectively used as a cosmetic ingredient.

느릅나무(Ulmus davidiana var. Japonica)는 한국이나 중국 등에서 오래 전부터 전통의 민간요법으로 열매, 뿌리를 염증 및 종창 환부에 도포하여 항염제로 이용하거나, 중탕 추출하여 소화기 궤양 및 종양 등에 사용하여 왔다. 또한 한방에서는 유근피가 다량의 점액과 탄닌을 함유하고 있어 완화제, 치습, 이뇨, 소종독(消腫毒) 등에 이용하여 오고 있다. 본 연구에서는 유근피로부터 다당류를 분리 정제한 후 화장료 조성물로써의 사용 가능성을 확인하고자, 유근피 추출 다당류의 보습효과 및 소염효과 등을 조사하였다. 유근피에서 침출법으로 다당류를 분리정제한 후 가수 분해하고, 가수분해 생성물을 HPLC로 분석하여 주구성 당분이 람노오스, 갈락토오스, 글루코오스 등임을 확인하였고 GPC로 측정한 평균분자량은 20,000이었다. Corneometer CM820 등을 이용한 보습효능 실험 결과 히알루론 산과 견줄만한 효능을 확인할 수 있었으며, carrageenin에 의해 유도된 부종억제 효능 실험에서는 ketoprofen에 버금가는 좋은 효능을 나타내었다. 결론적으로 유근피 추출 다당류가 좋은 화장료 조성물로써 유용하게 사용될 수 있음을 확인하였다.

Keywords

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