Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Comparative Studies of the Electroacupuncture with Different Frequency and Duration Time in the Carrageenan-injected Rats

Carrageenan유발 동통에 대한 전침의 빈도와 시간에 따른 완화 효과

  • Choi Byung Tae (Department of Anatomy, College of Oriental Medicine, Dongeui University) ;
  • Choi Yung Hyun (Department of Biochemistry, College of Oriental Medicine, Dongeui University) ;
  • Lee Yang Tae (Department of Physiology, College of Oriental Medicine, Research Institute of Oriental Medicine, Dongeui University)
  • 최병태 (동의대학교 한의과대학 해부학교실) ;
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 이용태 (동의대학교 한의과대학 생리학교실 및 한의학연구소)
  • Published : 2004.02.01
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Abstract

We investigated the comparative effect with different frequency and duration time of electroacupuncture(EA) for suppression of pain. Inflammation was induced by an intraplantar injection of 1 % carrageenan into the right hind paw. Bilateral EA stimulation with 2 Hz, 15 Hz and 120 Hz were delivered at those acupoints corresponding to Zusanli and Sanyinjiao in man via the needles in carrageenan-injected rats. The paw and tail thermal hyperalgesia were measured in 30-minute intervals after carrageenan injection using hot plate and tail flick analgesia meter, respectively. The significant difference was found between the control and any of EA frequencies examined. Especially 2 Hz EA presented more effective inhibitory effects compared with other frequency of EA in tail flick latency. The hyperalgesia induced by carrageenan was strongly inhibited by 2 Hz EA from 5 min post and reached sufficient effects from 20 min post EA treatment. These results suggest that EA treatment might be a useful therapy for mitigation of inflammatory pain.

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References

  1. NeuroReport v.9 OFQ reverses the k opioidreceptor-mediated depression of calcium current in rat dorsal root ganglion neurons Zhang, M.;Sun, Q.;Wan, Y.;Yao, L.;Yu, Y.;Han, J.S. https://doi.org/10.1097/00001756-199806220-00034
  2. Int. J. Neurosci. v.82 Changes in the content of immunoreactive dynorphin in dorsal and ventral spinal cord of the rat in three different conditions Xue, J.C.;Yu, Y.X.;Han, J.S. https://doi.org/10.3109/00207459508994293
  3. Int. J. Neurosci. v.65 Comparison of the antinociceptive effects induced by electroacupuncture and transcutaneous electrical nerve stimulation in the rat Wang, J.Q.;Mao, L.;Han, J.S. https://doi.org/10.3109/00207459209003283
  4. Neurosci. Lett. v.207 C-fos proteins are not involved in the activation of preproenkephalin gene expression in rat brain by peripheral electric stimulation Guo, H.F.;Cui, X.;Hou, Y.;Tian, J.;Wang, X.;Han, J.S. https://doi.org/10.1016/0304-3940(96)12523-4
  5. Neurosci. Lett. v.294 Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electro- acupuncture stimulation Huang, C.;Wang, Y.;Chang, J.K.;Han, J.S. https://doi.org/10.1016/S0304-3940(00)01572-X
  6. Z. Rheumatol. v.60 Nociception, pain, and antinociception: current concepts Riedel, W.;Neeck, G. https://doi.org/10.1007/s003930170003
  7. J. Pharmacol. Exp. Ther. v.283 Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production Zhang, Y.;Shaffer, A.;Portanova, J.;Seibert, K.;Isakson, P.C.
  8. Pharmacol. Res. v.49 Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat Abdel-Salam, O.M.;Baiuomy, A.R.;El-batran, S.;Arbid, M.S. https://doi.org/10.1016/j.phrs.2003.08.004
  9. Neuroscience v.93 The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord Ebersberger, A.;Grubb, B.D.;Willingale, H.L.;Gardiner, N.J.;Nebe, J.;Schaible, H.G. https://doi.org/10.1016/S0306-4522(99)00164-5
  10. Behav. Brain Res. v.47 Analgesia induced by electroacupunc- ture of different frequencies is mediated by different types of opioid receptors: another cross-tolerance study Chen, X.H.;Han, J.S. https://doi.org/10.1016/S0166-4328(05)80120-2
  11. Am. J. Chin. Med. v.8 Central neurotransmitters and acupuncture analgesia Han, J.S.;Tang, J.;Ren, M.F.;Zhou, Z.F.;Fan, S.G.;Qiu, X.C. https://doi.org/10.1142/S0192415X80000311
  12. Prog. Neurobiol. v.57 The induction of pain: an integrative review Millan, M.J. https://doi.org/10.1016/S0301-0082(98)00048-3
  13. Neuroscience v.64 Is there more than one prostaglandin E receptor subtype mediating hyperalgesia in the rat hindpaw? Khasar, S.G.;Ouseph, A.K.;Chou, B.;Ho, T.;Green, P.G.;Levine, J.D. https://doi.org/10.1016/0306-4522(94)00423-3
  14. Z. Rheumatol. v.57 Efferent functions of C-fiber nociceptors Sann, H.;Pierau, F.K. https://doi.org/10.1007/s003930050226
  15. Brain Res. v.581 Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography Matsumura, K.;Watanabe, Y.;Imai-Matsumura, K.;Connolly, M.;Koyama, Y.;Onoe, H.;Watanabe. Y. https://doi.org/10.1016/0006-8993(92)90720-T
  16. Behav. Brain Res. v.47 Analgesia induced by electroacupuncture of different frequencies is mediated by different types of opioid receptors: another cross-tolerance study Chen, X.H.;Han, J.S. https://doi.org/10.1016/S0166-4328(05)80120-2