Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Puerariae Radix on HSP70 Expression in Ischemic Damaged Rats

갈근이 뇌허혈 손상 흰쥐의 해마 구역별 HSP70 발현에 미치는 영향

  • Kim Youn Sub (Department of Anatomy-Meridian, College of Oriental Medicine, Kyungwon University)
  • 김연섭 (경원대학교 한의과대학 해부경혈학교실)
  • Published : 2004.02.01
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Abstract

This study investigated a HSP70 expression of Puerariae Radix in cerebral ischemia. The global cerebral ischemia was induced by bilateral common carotid arteries occlusion under hypotension (40 mmHg) in Sprague-Dawley rats. After the treatment of Puerariae Radix extract, the heat shock protein 70 (HSP70) expressions were measured immunohistochemically. The upregulation of HSP70 expression in hippocampal regions resulted by cerebral ischemia. Then Puerariae Radix treatment demonstrated significant decrease of HSP70 expressions in CA1 region and dentate gyrus of the hippocampus as compared with control group. These results suggested that Puerariae Radix reveals the neuroprotective effect through the control of noxious stress stimulations to neurons.

Keywords

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