동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제18권1호
  • /
  • Pages.122-136
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  • 2004
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

CIA 생쥐의 관절염 유발에 대한 청열사습탕가미방의 억제 효과

Inhibitory Effect of Ceongryulsaseuptang-kami on Arthritis occurrence in Collagen Induced Arthritis Mouse

  • 조종철 (대전대학교 한의과대학 병리학교실) ;
  • 박종오 (대전대학교 한의과대학 병리학교실) ;
  • 이용구 (대전대학교 부속한방병원) ;
  • 신현규 (한국한의학연구원) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Cho Jang cheal (Department of Oriental Medicine, College of Oriental Medicine. Daejeon University) ;
  • Park Jang ah (Department of Oriental Medicine, College of Oriental Medicine. Daejeon University) ;
  • Lee Yang koo (Daejeon University Oriental Hospital) ;
  • Shin Hyun kyu (Korea Institute of Oriental Medicine) ;
  • Kim Dong hee (Department of Oriental Medicine, College of Oriental Medicine. Daejeon University)
  • 발행 : 2004.02.01
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초록

To evaluate effect of CRSST on inhibiting the occurrence of arthritis, we performed the experiments including production of inflammatory cytokine and immunoglobin in collagen induced arthritis model. The results were obtained as follows. CRSST extract shows any cytotoxicity effect on mouse lung fibroblast cells at dose of 400 ㎍/㎖. CRSST group shows inhibitory effect on arthritis incidence than control group for six weeks. Arthritis index of CRSST group reduces from 4 weeks (75±17.4%) to 6 weeks (33.3±10.0%) compared with control group. In CRSST group, production of cytokines which shows suppressive effect on inflammation (IL-4, IL-10 ) are increased and which promotes inflammation (TNF-α, INF-γ) are decreased in blood. In CRSST group, production of immunogloblin (IgG2b, IgG3 and IgM) is reduced compared with control group, and rate of CD4+ and CD3+ T cell is lower in joint and higher in lymph node compared with control group. From above results it could be accepted that CRSST shows anti-arthritis effect via immune system especially through the controlling the inflammatory cytokines and immunoglobins. CRSST could be usefully applied for the prevention and treatment of RA. And also is expected to be clinically helpful on the treatment of RA through modification.

키워드

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