Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-inflammatory Effect of Baenong-san in Proteinase-activated Receptor-2-mediated Paw Edema

배농산이 프로테이나아제 활성수용체-2에 의한 흰쥐 발바닥 부종에 미치는 항염효과

  • Lim Jong Pil (Department of Oriental Pharmacy, Woosuk University) ;
  • Cui Xun (Department of Oriental Pharmacy, Woosuk University)
  • 임종필 (우석대학교 한약학과) ;
  • 최훈 (우석대학교 한약학과)
  • Published : 2004.02.01
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Abstract

The Baenong-san has long been used for treatment of inflammatory in Korea. In this study, the anti-inflammatory effects of Baenong-san water extract (BWX) were investigated in proteinase-activated receptor-2 (PAR2)-mediated rat paw edema. Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH₂ (to-NH₂) into hindpaw of rats. BWX (10, 50, 100 and 200mg/kg) was orally administered 1 h before induction of inflammation. At doses of 50, 100 and 200 mg/kg, BWX showed significant inhibition of both change in paw volume and vascular permeability. BWX(100mg/kg) significantly also inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity in paw tissue. This study demonstrated that BWX has an anti-inflammatory action for PAR2-mediated paw edema.

Keywords

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