Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Immune Function-enhancing Effects of Bojungikkitanggami-bang

보중익기탕가미방의 면역기능 증진 효과

  • Lee Sang Hun (Department of Internal Medicine, College of Oriental Medicine Wonkwang University) ;
  • Lee Seung Eon (Department of Internal Medicine, College of Oriental Medicine Wonkwang University) ;
  • Lee Si Hyeong (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Shin Jo Young (Department of Internal Medicine, College of Oriental Medicine Wonkwang University)
  • 이상훈 (원광대학교 한의과대학 폐계내과학교실) ;
  • 이승언 (원광대학교 한의과대학 폐계내과학교실) ;
  • 이시형 (원광대학교 한의학전문대학원) ;
  • 신조영 (원광대학교 한의과대학 폐계내과학교실)
  • Published : 2004.04.01
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Abstract

The immune system acts to protect the host from infectious agents that exist in the environment and from other noxious insults. The immune system has two functional divisions: the innate and the acquired. Both components involve various factors such as cytokines. A number of methodologies exist to assess aspects of immune function. There are large inter-individual variations in many immune functions even among the healthy. Genetics, age, gender, smoking habits, habitual levels of exercise, alcohol consumption, diet, stage in the female menstrual cycle, stress, history of infections and vaccinations, and early life experiences are likely to be important contributors to the observed variation. While it is clear that individuals with immune responses significantly below 'normal' are more susceptible to infectious agents and exhibit increased infectious morbidity and mortality, it is not clear how the variation in immune function among healthy individuals relates to variation in susceptibility to infection. Oriental medicine is an important factor contributing to immune competence. The author investigated the immune enhancement effects of Bojungikkitanggami-bang (BITB). The forced swimming test (FST) has been used as a screening model for new immune enhancement agents. In the present study, the author investigated the effects of BITB on FST and blood biochemical parameters related to fatigue, glucose (Glc); blood urea nitrogen (BUN); lactate dehydrogenase (LDH); creatinine; and total protein (TP). The author found that BITB (1 g/kg) significantly reduced the immobility time in the FST compared to the control. In addition, the contents of Glc, LDH, BUN, TP in the blood serum were increased in BITB (1g/kg)-fed group. Also, the author investigated the effects of BITB on the production of cytokines in human T-cell line, MOLT-4 cells. BITB (1 mg/ml) significantly increased the interferon (IFN)-vproduction compared with media control (about 2.2-fold for IFN-γ) at 24 h. However, BITB has not affect the production of IL-2 and IL-4. In addition, BITB increased the protein expression level of IFN-γ in MOLT-4 cells. Thus, BITB may have therapeutic value in generating or enhancing immune function in a clinical setting.

Keywords

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