Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Apoptosis-inducing Effect of Herba Patriniae Extract in the Prostate Cancer LNCaP Cells

전립선 암세포에서 패장 추출물의 세포고사 유도 효과

  • Moon Hyung Cheal (Department of Acupuncture & Moxibustion, School of Oriental Medicine, Wonkwang University)
  • 문형철 (원광대학교 한의과대학 침구학교실)
  • Published : 2004.06.01
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Abstract

Herba Patriniae(HP) has been known to exert anti-inflammation and -tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that HP extract induced apoptosis in androgen-dependent prostate cancer LNCaP cells as evidenced by DNA fragmentation. Our data demonstrated that HP extract-induced apoptotic cell death was accompanied by inhibition of NF- κB activation, lowering effects of intracellular prostate specific antigen(PSA) and androgen reoeptor(AR) expression in a time dependent manner. Taken together, HP extract may inhibit the proliferation of prostate cancer LNCaP cell associated with inhibition of NF- κB activation, PSA and AR expression and that of apoptosis.

Keywords

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