The Effects of Hibiscus Syriacus Extract on the Alzheimer's Disease Mice Model Induced by $\betaA$

목근피가 $\betaA$로 유도된 Alzheimer's Disease 생쥐 모델에 미치는 영향

  • Lee Sang Ryong (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University) ;
  • Jung In Chul (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
  • 이상룡 (대전대학교 한의과대학 신경정신과학교실) ;
  • 정인철 (대전대학교 한의과대학 신경정신과학교실)
  • Published : 2004.06.01

Abstract

This research investigates the effect of the Hibiscus syriacus(HSS) on Alzheimer's disease. The effects of the HSS extract on the behavior in the Morris water maze experiment; the expression of IL-1β, TNF-α, IL-1β mRNA, TNF-α mRNA, CD68/GFAP and RDS; the the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with M were investigated. The HSS extract group showed a significant inhibitory effect on the memory deficit on the mice with Alzheimer's disease induced by βA in the Morris water maze experiment. The HSS extract group suppressed the over-expression of IL-1β, TNF-α, IL-1β and TNF-α mRNA, CD68/GFAP, RDS in the mice with Alzheimer's disease induced by βA. The HSS extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by βA. This study suggest that HSS may be effective for the prevention and treatment of Alzheimer's disease

Keywords

References

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