Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Socheongryong-tang and Kamichihyo-san on Mucin Secretion from Airway Goblet

소청용탕 및 가미치효산이 평흡기 배장세포로부터의 뮤신 분비에 미치는 영향

  • Na Do gyun (Department of internal Medicine, College of Oriental Medicine Daejeon University) ;
  • Lee Choong Jae (Department of Pharmacology, College of Medicine Chungnam National University) ;
  • Park Yang Chun (Department of internal Medicine, College of Oriental Medicine Daejeon University)
  • 나도균 (대전대학교 한의과대학 내과학교실) ;
  • 이충재 (충남대학교 의과대학 약리학교실) ;
  • 박양춘 (대전대학교 한의과대학 내과학교실)
  • Published : 2004.06.01
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Abstract

In the present study, the author intended to investigate whether two oriental medical prescriptions named socheongryong-tang(SCRT) and Kamichihyo-san(KCHS) significantly affect mucin release from cultured hamster tracheal surface epithelial(HTSE) cells. Confluent HTSE cells were metabolically radiolabeled with ³H-glucosamine for 24 hrs and chased for 30 min in the presence of SCRT or KCHS to assess the effect of each agent on ³H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Also, the effects of SCRT and KCHS on contractility of isolated tracheal smooth muscle were investigated. The results were as follows: (1) SCRT significantly inhibited mucin release from cultured HTSE cells, without cytotoxicity; (2) KCHS significantly increased mucin release without cytotoxicity; (3) SCRT and KCHS did not affect contractility of isolated tracheal smooth muscle. We suggest that the effects of SCRT and its components should be further investigated and it is of great value to find, from oriental medical prescriptions, novel agents which have the possible inhibitory effects on mucin release from the viewpoint of management of hypersecretion of airway mucus.

Keywords

References

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