동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제18권4호
  • /
  • Pages.1140-1146
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  • 2004
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

대표적 보기약인 인삼, 당삼, 황기, 백출, 산약 물추출액의 면역조절효과 비교

Comparison of Immunomodualtory Effects of Water-extracted Ginseng Radix, Pilose Asia-bell, Astragali Radix, Astractylodes Rhizoma alba and Dioscoreae Rhizoma

  • 신상우 (대구한의대학교 한의과대학 병리학교실) ;
  • 이영선 (대구한의대학교 한의과대학 병리학교실) ;
  • 박종현 (대구한의대학교 한의과대학 병리학교실) ;
  • 권택규 (계명대학교 의과대학) ;
  • 서성일 (계명대학교 의과대학) ;
  • 권영규 (대구한의대학교 한의과대학 생리학교실)
  • Shin Sang Woo (Department of Pathology, College of Oriental Medicine, Daegu Haany University) ;
  • Lee Young Sun (Department of Pathology, College of Oriental Medicine, Daegu Haany University) ;
  • Park Jong Hyun (Department of Pathology, College of Oriental Medicine, Daegu Haany University) ;
  • Kwon Taeg Kyu (School of Medicine, Keimyung University) ;
  • Suh Seong Il (School of Medicine, Keimyung University) ;
  • Kwon Young Kyu (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
  • 발행 : 2004.08.01
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초록

This study was carried out to investigate the comparison of immunomodualtory effects of water-extracted Ginseng Radix(GR), Pilose Asia-bell(PA), Astragali Radix(AR), Astractylodes Rhizoma alba(AA) and Dioscoreae Rhizoma (DR). The parameter examined to assess apparent immunomodulatory effect of the water-extracted GR, PA, AR, AA and DR included the regulation of Nitric oxide (NO), the expression of Th1/Th2 type cytokine, the change of B cell phenotype. The water-extracted GR, PA, AR, AA and DR inhibited NO production and iNOS protein expression in LPS stimulated RAW 264.7 macrophage cells. In the Th1 and Th2 cytokine expression, the water-extracted GR, PA, AR, AA and DR induced IL-2 and IFNr mRNA gene expression. Therefore, it seems that the water-extracted GR, PA, AR, AA and DR have a inducing effect of Th1 type cytokines. In the Flow cytometry analysis, the water-extracted GR, PA, AR, AA and DR did not change B cell phenotype (CD45R/B220). The water-extracted GR, PA, AR, AA and DR have a reducing effect of immune suppression cause by Methotrexate (MTX), an agent of immune suppression. These results suggest that the immunomodulatory effects of the water-extracted GR, PA, AR, AA and DR may be, in part, associated with the inducing IL-2 and IFNr mRNA gene expression in and regulation of NO production in macrophage cells.

키워드

참고문헌

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