Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Induction of Apoptotic Cell Death by an Aqueous Extract of Cordyceps militaris in A549 Human Lung Carcinoma Cells

동충하초의 인체 폐암세포 증식억제에 관한 연구

  • Hong Sang Hun (Department of Oriental Medicine, Dongeui University) ;
  • Kam Chul Woo (Department of Oriental Medicine, Dongeui University) ;
  • Park Dong-Il (Department of Oriental Medicine, Dongeui University)
  • 홍상훈 (동의대학교 한의과대학 내과학교실) ;
  • 감철우 (동의대학교 한의과대학 내과학교실) ;
  • 박동일 (동의대학교 한의과대학 내과학교실)
  • Published : 2004.08.01
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Abstract

To investigate the anti-proliferative effects of an aqueous extract of Cordyceps militaris (AECM) on the growth of human lung carcinoma cell line A549, we performed various biochemical experiments such as the effects of AECM on the cell proliferation and viability, the morphological changes, the effects on expression of apoptosis and cell growth-regulatory gene products. Results obtained are as follow; AECM treatment declined the cell viability and proliferation of A549 cells in a concentration-dependent manner. The anti-proliferative effect by AECM treatment in A549 cells was associated with morphological changes such as membrane shrinking and cell rounding up. Taken together, these findings suggest that AECM-induced inhibition of human lung cancer cell proliferation is associated with the induction of apoptotic cell death via regulation of several major growth regulatory gene products, and C. militaris may have therapeutic potential in human lung cancer.

Keywords

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