The Pro and Post Effects of Soshiho-tang on Rat's Liver Damage induced by $CCl_4$

소자호탕이 $CCl_4$로 유발된 Rat의 간 장해 전후에 미치는 영향

  • Dang Chung Woon (Department of Physiology, College of Oriental Medicine, Sangji University) ;
  • Han Kyung Hee (Department of Physiology, College of Oriental Medicine, Sangji University) ;
  • Han Sang Mook (Department of Physiology, College of Oriental Medicine, Sangji University) ;
  • Kim Myung Dong (Department of Physiology, College of Oriental Medicine, Sangji University)
  • 당청운 (상지대학교 한의과대학 생리학교실) ;
  • 한경희 (상지대학교 한의과대학 생리학교실) ;
  • 한상묵 (상지대학교 한의과대학 생리학교실) ;
  • 김명동 (상지대학교 한의과대학 생리학교실)
  • Published : 2004.10.01


In studying the specific effects of some drugs, animals under experiments get some stress through laboratory environments, drug injection, and adaptation period. These stimuli do harms on liver function. Nowadays studies on liver intoxication and its protection are under research, but the function of dissolution is rarely under studies. It is widely accepted that Soshiho-tang has function of clearing away low spirits, and that it enables liver bloods to move stronger, and to have calm mind. So I injured rats liver by injectioning CCI₄. And the rats took in Soshiho-tang solution. I made a comparison between the functions before and after rat's liver damage. There are many representative serums used to note an index on liver damage. I used total protein, albumin, ALP, GOT, GPT activity, P450, SOD, Catalase, GST, GR, and GPx. I got the following results. When Soshiho-tang was injected after CCI4 intoxication, total protein and albumin decreased. When Soshiho-tang was injected, ALP decreased, compared with control group. When Soshiho-tang was injected after CCI₄ intoxication, AST and ALT decreased. When Soshiho-tang was injected before CCI₄ intoxication, P450 was restrained. When Soshiho-tang was injected, LPO was all restrained. When Soshiho-tang was injected, SOD, Catalase, GST, GR, and, GPx increased. These results show that blood test reveals that it is good to inject Soshiho-tang after CCI₄ intoxication, but that it is good to inject Soshiho-tang before CCI₄ intoxication in case of P450, LPO, SOD, Catalase, GST, GR, and GPx. It is estimated that the medication period and time of liver damage by CCI₄ have counter results, and that it needs more modified study.



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