Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of the New Diabetic Formula on Streptozotocin-induced Diabetic Rats

Streptozotocin 당뇨모델에 대한 신당뇨방의 효과

  • Kim Hee Young (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Choi Bo Hee (Ilchim Oriental Clinic) ;
  • Hwang Hye Jeong (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim Hyuk (Kim-Hyuk Oriental Clinic) ;
  • Lee Kang Min (Department of Molecular biology, Chonbuk National University) ;
  • Hahm Dae Hyun (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Shim Insop (Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lee Hye Jung (Graduate School of East-West Medical Science, Kyung Hee University)
  • Published : 2004.10.01
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Abstract

The present study evaluated the beneficial effect of new diabetic formula(NDF) in diabetic rats. Adult Sprague-Dawley rats weighing 250-300 g were used. Diabetes mellitus was induced by intramuscular injections of streptozotocin(STZ, 50㎎/㎏). The extracts of NDF were orally administered at low or high dose two times a day to fasted diabetic rats for 3 weeks. Adminstration of NDF alliviated a significant reduction in weight gain in rats with STZ-induced diabetes. Following acute and repeated treatment, low dose of NDF suppressed the blood glucose concentrations of fasted diabetic rats. Repeated adminstration of NDF for 21 days improved liver and kidney functions in diabetic rats, as indicated by decline of serum alanine aminotransferase(AL T), alkaline phosphatase(ALP), blood urea nitrogen(BUN), creatinine level and kidney weights. The present study showed that NDF exerted antihyperglycemic effects and alliviated liver and renal damages caused by streptozotocin-induced diabetes.

Keywords

References

  1. Postgraduate Medicine v.85 Diabetes mellitus : control and complication Molitch EM
  2. Am J Med v.74 Effect of age and diet on insulin secretion and insulin action in the rat Reaven GM
  3. Br J Nutr v.80 Traditional plant treatment for diabetes mellitus: pharmaceutical foods Day C
  4. Br J Nutr v.80 Actions of traditional antidiabetic plant, Agrimony eupatoria(agrimony): effect on hyperglycemia, cellular glucose metabolism and insulin secretion Gray AM;Flatt PR
  5. Am J Chin Med. v.20 no.3;4 Crude drugs for the treatment of diabetes mellitus in Taiwan Lin CC
  6. 동의생리병리학회지 v.1 no.1 소갈에 응용되는 백호탕이 Alloxan 당뇨에 미치는 영향 김완희
  7. 경희한의대 논문집 죽력탕, 가미죽력탕이 고혈압 및 당뇨에 미치는 영향 이경섭
  8. 가미지황탕과 압척초 실험적 당뇨에 미치는 영향 정대규
  9. 경희대학교 논문집 가미육미지황탕이 streptozotocin 백서의 혈당량에 미치는 영향 허종회
  10. Planta Med v.61 no.4 Characterization of the hypoglycemic effects of Trigonella foenum graecum seed Ali L;Azad KAK;Hassan Z;Mosihuzzaman M;Nahar N;Nasreen T;Nurealam M
  11. Egypt J Appl Sci v.9 no.2 Effect of Balanites aegyptiaca on serum glucose and insulin level in normal and alloxan-diabetic mice Eskander EF
  12. Egyp J Pharm Sci v.33 Phytochemical examination and biological studies of Acacia nilotica L. wild and Acacia fanesiana L. wild growing in Egypt Wassel GM;Abd Elwahab SM;Ammar NM;Afifi MS
  13. J Ethnopharmacol v.50 Effect of Luffa aegyptiaca (seeds) and Carissa edulis (leaves) extracts on blood glucose level of normal and streptozotocin diabetic rats El-Fiky FK;Adou-Karam MA;Afify EA
  14. Egypt J Pharm Sci v.36 The hyperglycemic effect of different extracts of Ambrosia maritima, L, Compositae Nagwa MA;Sahar YA;Ibrahim HB
  15. J Agric Food Chem v.51 no.6 Protein glycation inhibitory and antioxidative activities of some plant extracts in vitro Kim HY;Kim K
  16. Arch Pharm Res v.23 no.3 Inhibitory effects of crude drugs on alpha-glucosidase Choi HJ;Kim NJ;Kim DH
  17. Yakigaku Zasshi v.115 no.6 Hypoglycemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocin- induced diabetic mice Chen F;Nakashima N;Kimura I;Kimura M.
  18. Cochrane Database Syst Rev v.3 Chinese herbal medicines for type 2 diabetes mellitus Liu J;Zhang M;Wang W;Grimsgaard S.
  19. Jpn J Pharmacol v.90 no.2 Adminstration of Folium mori extract decreases nitiric oxide synthase expression in the hypothalamus of streptozotocin-induced diabetic rats Jang MH;KIM H;Shin MC;Lim BV;Lee TH;Jung SB;Kim CJ;Kim EH
  20. Yakugaku Zasshi. v.121 no.5 Antidiabetic effect of folium mori in GK rats Iizuka Y;Sakurai E;Tanaka Y.
  21. Altern Ther Health Med v.10 no.3 Antihyperglycemic effects of propolis mixed with mulberry leaf extract on patients with type 2 diabetes Murata K;Yatsunami K;Fukuda E;Onodera S;Mizukami O;Hoshino G;Kamei T.
  22. Life Sci v.73 no.18 Garlic extract attenuates time-dependent changes in the reactivity of isolated aorta in streptozotocin-diabetic rats Baluchnejadmojarda T;Roghani M
  23. J Ethnopharmacol v.85 no.1 Beneficial effect of aqueous garlic extract on the vascular reactivity of streptozotocin-diabetic rats Baluchnejamojarad T;Roghani M;Homayounfar H;Hosseini M
  24. Phytomedicine v.10 no.6;7 Anti-hyperglycemic effects of ginseng : comparison between root and berry Dey L;Xie JT;Wang A;Wu J;Maleckar SA;Yuan CS
  25. Plant Physiol. v.133 no.1 Properties of fructan:fructan -fructosyltransferases from chicory and globe thistle, two Asteracean plants storing greatly different types of inulin Vergauwen R;Van LA;Van EW
  26. Br J Nutr v.74 no.1 Recovery of inulin from Helianthus tuberosus in the small intestine of man Bach Knudsen KE;Hessov I
  27. Vopr Med Khim v.43 no.4 Effect of oral inulin administration on the fructose 2, 6-biphosphate level in the liver tissue of rats with streptozotocin diabetes Guseva DA;Gordetskii VK;Kraevoi SA;Markova MS;Tsyganova TB
  28. Effects of luteolin 5-O-${\beta}$-rutinoside in streptozotocin-induced diabetic rats v.58 Zarzuelo A;Jimenez I;Gamez MJ;Utrilla P;Fernadez I;Torres MI;Osuna I
  29. J Ethnopharmacol v.78 Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats Adolfo AC;Helmut W
  30. Diabetologica v.31 Strict insulin treatment normalizes the organic nitrogen contents and the capacity of urea-N synthesis in experimental diabetes in rats Almdal TP;Vilstrup H
  31. Zhongguo Zhong Xi Yi Jie He Za Zhi. v.21 no.2 Effect of Acanthopanax senticosus injection on plasma and urinary endothelium in early stage of diabetic nephropathy Ni HX;Luo SS;Shao GM
  32. J Appl Toxicol. v.24 no.1 Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats Ozen S;Akyol O;Iraz M;Sogut S;Ozugurlu F;Ozyurt H;Odaci E;Yildirim Z
  33. Nippon Yakurigaku Zasshi v.97 no.2 Studies on antinephritic effects of plant components in rats : Effects of ginsenosides on original type anti-GBM nephritis in rats and its mechanism Hattori T;Ito M;Suzuki Y
  34. Food Chem Toxicol v.40 no.10 Antioxidative effects of fluvastatin and its metabolites against DNA damage in streptozotocin- treated mice Imaeda A;Kaneko T;Aoki T;Kondo Y;Nakamura N;Nagase H;Yoshikawa T
  35. Biotechnol. Appl. Biochem. v.38 Temporal response pattern of biochemical analytes in experimental diabetes Mori DM;Baviera AM;Vendramini RC;Brunetti IL;Pepato MT
  36. Plant Med v.59 Free radicals scavenger and antihepatotoxic activity of Rosmarinus Navarro CM;Montilla PM;Martin A;Jimenez J;Utrilla PM
  37. J Ethnopharmacol v.92 no.1 Effect of Acanthopanax koreanum Nakai(Araliaceae) on D-galactosamine and lipopolysaccharide-induced fulminant hepatitis Nan JX;Park EJ;Nam JB;Zhao YZ;Cai XF;Kim YH;Sohn DH;Lee JJ
  38. Planta Med v.70 no.4 Acanthoic acid from Acanthopanax koreanum protects against liver injury induced by tert-butyl hydroperoxide or carbon tetrachloride in vitro and in vivo Park EJ;Zhao YZ;Kim YH;Lee JJ;Sohn DH
  39. Drugs Exp Clin Res v.22 no.6 The protective effect of aqueous propolis extract on isolated rat hepatocytes against carbon tetrachloride toxicity Mahran LG;el-Khatib AS;Agha AM;Khayyal MT
  40. Biosci Rep v.21 no.1 Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats Ohaeri OC
  41. Comp Biochem Physiol A Mol Integr Physiol v.135 no.4 Oxidative stress in streptozotocin- induced diabetic rats : effects of garlic cell and melatonin Anwar MM;Meki AR
  42. J Vet Med Sci v.66 no.2 The effect of Korean red ginseng on liver regeneration after 70% hepatectomy in rats Kwon YS;Jang KH
  43. Life Sci v.69 no.6 Protective effect of polysaccarides-enriched fraction from Angelica sinensis on hepatic injury Ye YN;Liu ES;Li Y;So HL;Cho CC;Sheng HP;Lee SS;Cho CH
  44. Anticancer Res v.22 Non-toxic potentiation of cancer radiotherapy by dietary oligofructose or inulin Taper HS;Roberfroid MB
  45. J Biosci v.27 no.7 Application of inulin and oligofructose in health and nutrition Kaur N;Gupta AK
  46. J. Nutr. v.129 no.7 Teas and other beverages suppress D-galactosamine-induced liver injury in rats Sugiyama K;He P;Wada S;Saeki S
  47. J Ethnopharmacol v.87 no.1 Cholesterol-lowering activity of the aqueous extract of Spergularia purpurea in normal and recent-onset diabetic rats Jouad H;Lemhadri A;Maghrani M;Zeggwagh NA;Eddouks M
  48. Scand J Clin Lab Invest v.52 no.7 Effect of emeriamine on excrine and endocrine pancreatic function in normal and diabetic rats Duan RD;Cheng Y;Erlanson-Albertsson C