Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Screening of the Biologoical Activity from Water Extracts of the Medicinal Plants and the Protective Effect of R. palmatum on MTPT-induced Neurotoxicity

한약재 물 추출물의 생리활성 검색 및 MPTP-유도 신경독성에 대한 대황의 보호효과

  • Kim Tae Eun (Department of Physiology, College of Oriental Medicine, Sangji University) ;
  • Yoon Yeo Min (Department of Physiology, College of Oriental Medicine, Sangji University) ;
  • Park Yong In (Department of Physiology, College of Oriental Medicine, Sangji University) ;
  • Kim Youn Seok (Department of Rehabilitation, Joong Hwa Oriental Medical Hospital) ;
  • Jeon Byung Hun (Department of Pathology, College of Oriental medicine, Wonkwang University) ;
  • Kim Myung Dong (Department of Physiology, College of Oriental Medicine, Sangji University)
  • 김태은 (상지대학교 한의과대학 생리학교실) ;
  • 윤여민 (상지대학교 한의과대학 생리학교실) ;
  • 박용인 (상지대학교 한의과대학 생리학교실) ;
  • 김윤석 (중화한방병원) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실) ;
  • 김명동 (상지대학교 한의과대학 생리학교실)
  • Published : 2004.12.01
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Abstract

This present study was designed to screen medicinal plants for the treatment of brain diseases such as Parkinson's disease or aging. We tested the effects of the water extracts from 38 species medicinal plants on antioxidant capacity, monoamine oxidase B (MAO-B) inhibitory activity, acetylcholinesterase (AChE) inhibition and antiperoxidation activity in vitro. The water extracts from 38 species were tested on their antioxidant activity using radical scavenging effects against ABTS+. The water extract of C. sappan was showed the highest antioxidant capacity, the antioxidant activity at 1 Jig of herbal extract being 0.38mM TE. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe/sup 2+/ was strong inhibited by C. sappan and R. palmatum extracts. Among the 38 medicinal plants investigated, R. palmatum showed significant biological activity (antioxidant capacity, MAO-B inhibiory activity, and AChE inhibitory activity). The protective efficacy of R. palmatum water extract on 1-methyl-4­phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism and its possible mechanism were studied in C57BL/6 mice. Treatment of R. palmatum water extract protected biomacromolecules such as lipids from oxidative damage induced by MPTP. The content of MDA in brain tissue was decreased significantly by R. palmatum extract. These results suggest that R. palmatum water extract plays on effective role in attenuating MPTP-induced neurotoxicity in mice. This protective effect of R. palmatum might be estimated the result from the inhibitory activity on monoamine oxidase B and the enhancement of antioxidant activity.

Keywords

References

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