대한의생명과학회지 (Biomedical Science Letters)
- 제10권3호
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- Pages.269-273
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- 2004
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Effect of Ferulic Acid on Cell Viability and Cell Adhesion Activity in Normal Human Gingival Fibroblasts
- Lee Joo-Hyun (College of Dental Medicine, Wonkwang University) ;
- Jin Byung-Jo (College of Dental Medicine, Wonkwang University) ;
- Son Il-Hong (School of Medicine, Wonkwang University) ;
- Han Du-Seok (College of Dental Medicine, Wonkang University)
- 발행 : 2004.09.01
초록
This study was designed to investigate the effect of ferulic acid on cell viability and cell adhesion activity in normal human gingival fibroblasts. The cell viability and cell adhesion activity of ferulic acid was measured by MTT assay or XTT assay, respectively, after normal human gingival fibroblasts were treated with or without ferulic acid for 48 hours. The cell viability of ferolic acid on normal human gingival fibroblasts did not show any decreasement by MTT assay and also, cell adhesion activity did not decreased by XTT assay, respectively, compared with control after cells were treated with various concentrations of ferolic acid for 48 hours. MTT/sub 50/ and XTT/sub 50/ were 2,130.0 μM and 1,773.7 μM ferolic acid, respectively. These results suggest that ferolic acid is non-toxic to normal human gingival fibroblasts by showing no significant differences in the cell viability and the adhesion activity compared with control by colorimetric assay.