The Journal of Korean Medicine (대한한의학회지)
- Volume 25 Issue 4
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- Pages.209-219
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- 2004
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
Study on the Relationship between Candidate Genes of Cerebral Infarction and Sasang Constitution
- Park Hye-Sun (Department of Sasang Constitutional Medicine, College of Oriental Medicine, Donshin University) ;
- Kim Kyung-Yo (Department of Sasang Constitutional Medicine, College of Oriental Medicine, Donshin University) ;
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Joo Jong-Cheon
(Department of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang University) ;
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Kim Jong-Yeol
(Department of Medical Research, Korea Institute of Oriental Medicine)
- Published : 2004.12.01
Abstract
The author investigated whether ACE/DD, AGN/TT, and ApoE/ε4 genotypes are associated with CI and whether genetic risk is enhanced by Sasang constitutional classification. The author ascertained these genotypes in patients with CI (n=211), diagnosed by brain computed tomography. Control subjects for the infarction group were randomly selected from 319 subjects matched for age, gender, and history of hypertension with patients. The ACE/DD genotype was not associated with CI. However. there was significant association between ApoE polymorphism and CI (x²=15.089, p<.05). Furthermore, frequency of AGN/TT genotype was higher in the patients with CI than in the controls (x²=20.072, p<.05). The frequency of T allele Was 0.91 in patients and 0.82 in controls (x²=17.237, p<.05). However, the Sasang constitutional classification did not increase the relative risk for CI in the subjects with ApoE/ε4 or AGN/T allele. These results suggest that ApoE and AGN polymorphism predict CI. but Sasang constitutional classification does not enhance the risk for CI associated with ApoE/ε4 or AGN/TT in a Korean population.
Keywords
- Cerebral infarction;
- ACE polymorphism;
- Apo E polymorphism;
- AGN polymorphism;
- Sasang constitution;
- Korean population