대한한의학회지 (The Journal of Korean Medicine)
- 제25권4호
- /
- Pages.36-42
- /
- 2004
- /
- 1010-0695(pISSN)
- /
- 2288-3339(eISSN)
Study on the Relationship between Polymorphisms in Glutathione S-transferase and Ischemic Cerebrovascular Disease
- Han Sang-Hyuk (Professional Graduate School of Oriental Medicine, Wonkwang University, Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
- Park Sae-Wook (Professional Graduate School of Oriental Medicine, Wonkwang University, Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
- Shin Yong-Il (Department of Rehabilitation Medicine, College of Medicine, Wonkwang University) ;
- Cho Kwang-Ho (Professional Graduate School of Oriental Medicine, Wonkwang University, Department of Neurology, College of Medicine, Wonkwang University) ;
- Moon Byung-Soon (Professional Graduate School of Oriental Medicine, Wonkwang University, Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
- 발행 : 2004.12.01
초록
Objective : Glutathione S-transferase polymorphism (GST) were examined in 120 cases with ischemic cerebrovascular disease (ICVD) to test the hyperthesis that GST polymorphisms confer a risk to an individual to develop ICVD. Tobacco smoking is a major cause of both cancer and vascular disease. Methods : therefore We were stratified the subjects with ICVD for smoking status, and then examined whether polymorphisms in this detoxification enzyme gene, GST, influence risk of ICVD Results : Neither GSTM1 nor GSTT1 genotypes in the ICVD group was significantly different from the control group (n=207), even in smokers. We attempted the combined analyses for GSTM1 and GSTT1 genotypes in ICVD for smoking status. No significant association observed between the combined genotypes and ICVD Conclusion : Our observation do not confirm the effect of the GSTM1 and GSTT1 genotypes as a risk factor for ICVD, even in smokers.
키워드