The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Study on the Relationship between Polymorphisms in Glutathione S-transferase and Ischemic Cerebrovascular Disease

  • Han Sang-Hyuk (Professional Graduate School of Oriental Medicine, Wonkwang University, Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Park Sae-Wook (Professional Graduate School of Oriental Medicine, Wonkwang University, Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Shin Yong-Il (Department of Rehabilitation Medicine, College of Medicine, Wonkwang University) ;
  • Cho Kwang-Ho (Professional Graduate School of Oriental Medicine, Wonkwang University, Department of Neurology, College of Medicine, Wonkwang University) ;
  • Moon Byung-Soon (Professional Graduate School of Oriental Medicine, Wonkwang University, Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • Published : 2004.12.01
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Abstract

Objective : Glutathione S-transferase polymorphism (GST) were examined in 120 cases with ischemic cerebrovascular disease (ICVD) to test the hyperthesis that GST polymorphisms confer a risk to an individual to develop ICVD. Tobacco smoking is a major cause of both cancer and vascular disease. Methods : therefore We were stratified the subjects with ICVD for smoking status, and then examined whether polymorphisms in this detoxification enzyme gene, GST, influence risk of ICVD Results : Neither GSTM1 nor GSTT1 genotypes in the ICVD group was significantly different from the control group (n=207), even in smokers. We attempted the combined analyses for GSTM1 and GSTT1 genotypes in ICVD for smoking status. No significant association observed between the combined genotypes and ICVD Conclusion : Our observation do not confirm the effect of the GSTM1 and GSTT1 genotypes as a risk factor for ICVD, even in smokers.

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