Imaging Science in Dentistry
- Volume 34 Issue 1
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- Pages.35-48
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- 2004
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- 2233-7822(pISSN)
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- 2233-7830(eISSN)
Effect of rhBMP-2 on the healing of bone defect in the low calcium diet rat
rhBMP-2가 저칼슘식이 투여 백서의 골결손부 치유에 미치는 영향
- Choi Yong-Suk (Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University) ;
- Hwang Eui-Hwan (Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University) ;
- Lee Sang-Rae (Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University)
- Published : 2004.03.01
Abstract
Purpose: To investigate the effect of rhBMP-2 on the healing of bone defect in the low calcium diet rat. Materials and Methods: To prepare the experimental model, control group was fed a normal diet and experimental group was fed a low calcium diet for 3 weeks. And then, 4 mm bicortical perforated bone defect was made on mandibular body of each rats. Experimental group was subdivided into two groups; experimental group 1 (rats given a low calcium diet before and after bone defect) and experimental group 2 (rats given a low calcium diet before and after bone defect with rhBMP-2 application). At 1, 3, 5 and 7 weeks after bone defect formation, the rats were terminated. The healing of bone defect was assessed by three-dimensional computerized tomography, soft x-ray radiography, and histopathological examination. Results : The wound healing of the bone defect for control group, experimental group 1, and experimental group 2 showed a increase from 3 weeks after bone defect formation. The experimental group 2 showed a more increase in healing amount than control group and experimental group 1 from 5 weeks after bone defect formation and the experimental group 2 showed a complete recovery of bone defect at 7 weeks after bone defect formation. Conclusion: The healing process of bone defect is accelerated by rhBMP-2 application in the low calcium diet rats.