한국전문물리치료학회지 (Physical Therapy Korea)
- 제11권2호
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- Pages.47-63
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- 2004
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- 1225-8962(pISSN)
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- 2287-982X(eISSN)
침전극 저주파자극이 흰쥐의 Caspase-3, 9와 Neuronal Nitric Oxide Synthase 면역반응세포 변화에 미치는 영향
The Effect of Needle Electrode Electrical Stimulation on the Change of Caspase-3, 9 and Neuronal Nitric Oxide Synthase Immunoreactive Cells in the Sprague Dawley Rats
- 김수한 (가야대학교 작업치료학과) ;
- 최흥식 (한서대학교 물리치료학과) ;
- 김택훈 (한서대학교 물리치료학과) ;
- 신헌석 (한서대학교 물리치료학과) ;
- 김지성 (용인대학교 물리치료학과) ;
- 송치원 (국립독성학연구소 신경독성과)
- Kim, Soo-Han (Dept. of Occupational Therapy, Kaya University) ;
- Choi, Houng-Sik (Dept. of Physical Therapy, Hanseo University) ;
- Kim, Tack-Hoon (Dept. of Physical Therapy, Hanseo University) ;
- Cynn, Heon-Seock (Dept. of Physical Therapy, Hanseo University) ;
- Kim, Ji-Sung (Dept. of Physical Therapy, Yongin University) ;
- Song, Chi-Won (Division of neurotoxicology, National Institute Toxicological Research)
- 발행 : 2004.05.21
초록
In most tissues, apoptosis plays a pivotal role in normal development and in regulation of cell number. Therefore inappropriate apoptosis is revealed in a variety of diseases. This study was carried out to investigate the effects of acupuncture and needle electrode electrical stimulation on the change of caspase-3, 9 and neuronal nitric oxide synthase (nNOS) immunoreactive cells in the sprague dawley rats (SD rat). In immobilized SD rats (n=5), enhanced caspase-3 and caspase-9 expression were detected in the reticular part of substantia nigra, and enhanced nNOS was detected in the dorsolateral periaqueductal gray (DL-PAG) of midbrain and the paraventricular nucleus (PVN) of the hypothalamus using immunohistochemistry. Following the immobilization, acupuncture (n=5) and needle electrode electrical stimulation (n=5, 2 Hz) was applied at H