Development and Reproduction (한국발생생물학회지:발생과생식)
- Volume 8 Issue 2
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- Pages.85-89
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- 2004
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- 2465-9525(pISSN)
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- 2465-9541(eISSN)
Effect of DEHP Administration on Reproduction in Pregnant Mice Ⅰ. Effect of DEHP Administration on Reproductive Characteristic and Blood Hematological Values in Pregnant Mice
임신중인 생쥐에 DEHP 투여가 번식현상에 미치는 영향 Ⅰ. 임신중인 생쥐에 DEHP 투여가 분만 후 번식특성과 혈액성분에 미치는 영향
- Park, Dong-Heon (Division of Animal Resoure Science, College of Animal Resource Science, Kangwon National University) ;
- Jang, Hyun-Yong (Division of Animal Resoure Science, College of Animal Resource Science, Kangwon National University) ;
- Park, Choon-Keun (Division of Animal Resoure Science, College of Animal Resource Science, Kangwon National University) ;
- Cheong, Hee-Tae (Division of Animal Resoure Science, College of Animal Resource Science, Kangwon National University) ;
- Kim, Choung-Ik (Division of Animal Resoure Science, College of Animal Resource Science, Kangwon National University) ;
- Yang, Boo-Keun (Division of Animal Resoure Science, College of Animal Resource Science, Kangwon National University)
- 박동헌 (강원대학교 동물자원과학대학 동물자원학부) ;
- 장현용 (강원대학교 동물자원과학대학 동물자원학부) ;
- 박춘근 (강원대학교 동물자원과학대학 동물자원학부) ;
- 정희태 (강원대학교 동물자원과학대학 동물자원학부) ;
- 김정익 (강원대학교 동물자원과학대학 동물자원학부) ;
- 양부근 (강원대학교 동물자원과학대학 동물자원학부)
- Published : 2004.12.01
Abstract
This study is illustrated that 1) the effects of DEHP administration on body weight, sex ratio and litter size on 19 days in the prenatal period 2) the effects of reproductive organ weight and blood hematological values on 25 days postpartum in pregnant mice. DEHP was administrated to pregnant mice by intraperitoneal injection at 0, 0.5, 1.0 and 10.0mg/kg B.W from day 1 to day 16 in the gestation period with 5 times at 3 days interval. There were no significantly differences in the material body weight, litter size and sex ratio on 19 days in the prenatal period. The body weight of the fatal male mice was slightly lower in 1.0 and 10.0mg DEHP groups than in any other groups. The reproductive organ weight and hematological values in dam mice on 25 days postpartum were not affected by DEHP administration. The histological evaluation of ovary in dam mice on 25 days after dilivery was not different in all experimental groups, but the endometriosis and edema of uterus in dam mice were significantly decreased in 0.5mg DEHP group than that of control group.These results indicate that the administration of low concentration of DEHP was not affected on reproductive characteristic and blood hematological values in pregnant mice.
본 연구는 임신한 생쥐에 DEHP의 투여가 분만 후 생쥐의 번식기능과 태아의 성비에 미치는 영향을 검토하였다. 임신한 자성 생쥐에 DEHP을 투여한 후 임신 19일째에 임신한 자성의 체중, 태아의 체중, 태아수 및 태아성비를 조사한 결과, 실험개시시와 실험종료시 임신한 자성의 체중은 각 투여구간에 차이가 없었으며, 자