Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Reduction of Postoperative Adhesions by a Synthetic Solution of Sodium Carboxymethylcellulose and Dextran or Interceed Following Intestinal Anastomosis in Dogs

개의 장문합술에 있어서 Sodium Carboxymethylcellulose와 Dextran의 합제 및 Interceed

  • 장영규 (경상대학교 수의과대학 동물의학연구소) ;
  • 김현희 (경상대학교 수의과대학 동물의학연구소) ;
  • 이희천 (경상대학교 수의과대학 동물의학연구소) ;
  • 연성찬 (경상대학교 수의과대학 동물의학연구소) ;
  • 이효종 (경상대학교 수의과대학 동물의학연구소)
  • Published : 2004.12.01
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Abstract

The effectiveness of a synthetic solution of sodium carboxymethy1cellulose (SCMC) and dextran in the prevention of adhesion formation following intestinal anastomosis of intestine in dogs was elucidated and compared with Interceed. Following induction of adhesion on jejunum of dogs by resection and intestinal anastomosis, the dogs were infused with a synthetic solution of 1% SCMC and 10% dextran in saline in the abdominal cavity at the dose of 5ml/kg of body weight or treated with Interceed membrane. Fourteen days after operation, all the dogs showed adhesion of anastomotic sites to surrounding tissues. The average score of adhesion was 0.50, 0.60 and 0.80 in the dogs infused with the synthetic solution, Interceed membrane and saline solution, respectively. The synthetic solution showed better result of adhesion prevention than Interceed or saline solution. No significant change of body weight, vital signs, hematological values and side effects after operation was found in each group. Therefore, a synthetic solution which is combined with 1% SCMC and 10% dextran in saline can be effectively used for the prevention of adhesion formation comparable to Interceed membrane following intestinal anastomosis in the dogs.

Keywords

References

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