Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Myeloperoxidase Polymorphism and Vitamin C Levels during Pregnancy Affect Maternal Oxidative Stress and Their Neonatal Birth Weights

임산부의 Myeloperoxidase 유전자다형성과 혈중 비타민 C 수준에 따른 모체의 산화 스트레스와 출생체중

  • 박보현 (이화여자대학교 의과대학 예방의학교실) ;
  • 김영주 (이화여자대학교 의과대학 산부인과학교실, 이화여자대학교 의과학연구소) ;
  • 박은애 (이화여자대학교 의과대학 소아과학교실, 이화여자대학교 의과학연구소) ;
  • 이화영 (이화여자대학교 의과대학 해부학교실, 이화여자대학교 의과학연구소) ;
  • 하은희 (이화여자대학교 의과대학 예방의학교실, 이화여자대학교 의과학연구소) ;
  • 박종순 (이화여자대학교 의과대학 산부인과학교실) ;
  • 김정연 (이화여자대학교 의과대학 예방의학교실) ;
  • 홍윤철 (서울대학교 의과대학 예방의학교실) ;
  • 박혜숙 (이화여자대학교 의과대학 예방의학교실, 이화여자대학교 의과학연구소)
  • Published : 2004.09.01
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Abstract

This study aimed to determine the association of maternal oxidative stress and adverse pregnancy outcome with serum vitamin C concentration and a myeloperoxidase (MPO) genetic polymorphism during pregnancy. We investigated 450 pregnant women who visited Ewha Womans University Hospital for prenatal care during gestational weeks 24～28. During the second trimester, we measured serum vitamin C levels and urinary 8-hydroxyde-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) as an oxidative stress biomarker. We determined the presence of a maternal MPO polymorphism (G-to-A substitution at nucleotide 463) using a PCR-RFLP assay. We compared the level of oxidative stress and birth weight with the vitamin C concentration and the presence of the MPO polymorphism. The mean level of maternal oxidative stress tended to be higher and the birth weight lower for MPO type A/A than for types A/G and G/G. Vitamin C levels above the 75 percentiles were associated with reduced concentrations of urinary MDA and 8-OHdG but increased birth weight. Our data demonstrate that oxidative stress and neonatal birth weight are associated with the MPO genetic polymorphism, with the association modified by the maternal vita-min C levels.

Keywords

References

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