KIEE International Transactions on Electrophysics and Applications

The Korean Institute of Electrical Engineers (대한전기학회)
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An Integrated Cell Processor for Single Embryo Manipulation

  • Park, Jung-Yul (Microsystem Research Center, Korea Institute of Science and Technology) ;
  • Jung, Seng-Hwan (Digital Bio Technology) ;
  • Kim, Young-Ho (Microsystem Research Center, Korea Institute of Science and Technology) ;
  • Kim, Byung-Kyu (Microsystem Research Center, Korea Institute of Science and Technology) ;
  • Lee, Seung-Ki (School of Electrical, Electronic and Computer Engineering, Dankook University) ;
  • Ju, Byeong-Kwon (Microsystem Research Center, Korea Institute of Science and Technology)
  • Published : 2004.10.01
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Abstract

In this paper, we present a novel integrated cell processor to handle individual embryos. Its functions are composed of transporting, isolation, orientation, and immobilization of cells. These functions are essential for biomanipulation of single cells, and have been typically carried out by a proficient operator. The purpose of this study is the automation of these functions for safe and effective cell manipulation using a MEMS based cell processor. This device is realized with a relatively simple design and fabrication process. Experimental results indicate that it can act as an efficient substitute for essential but very tiresome and repetitive manual work while contributing significantly to the improvement of speed and success rate of operation by facilitating cell manipulation. The cell viability test for the device is studied through the distribution of mitochondria in mice embryos and cultivation of cells for 86h.

Keywords

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