Ocean and Polar Research

  • 제26권1호
  • /
  • Pages.59-64
  • /
  • 2004
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  • 1598-141X(pISSN)
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  • 2234-7313(eISSN)
한국해양과학기술원 (Korea Institute of Ocean Science & Technology)
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과산화아질산염과 DPPH 라디칼에 대한 해조추출물의 소거 활성 효과

Studies on Screening of Seaweed Extracts for Peroxynitrite and DPPH Radical Scavenging Activities

  • 이희정 (한국해양대학교 해양과학기술연구소) ;
  • 김유아 (한국해양대학교 해양과학부) ;
  • 박기의 (한국해양대학교 해양과학부) ;
  • 정현아 (한국해양대학교 해양과학기술연구소) ;
  • 유종수 (한국해양대학교 해양과학기술연구소) ;
  • 안종웅 (한국해양대학교 해양과학부) ;
  • 이범종 (인제대학교 화학과) ;
  • 서영완 (한국해양대학교 해양과학부)
  • Lee, Hee-Jung (Research Institute of Marine Science and Technology (RIMST), Korea Maritime University) ;
  • Kim, You-Ah (Division of Ocean Science, Korea Maritime University) ;
  • Park, Ki-Eui (Division of Ocean Science, Korea Maritime University) ;
  • Jung, Hyun-Ah (Research Institute of Marine Science and Technology (RIMST), Korea Maritime University) ;
  • Yoo, Jong-Su (Research Institute of Marine Science and Technology (RIMST), Korea Maritime University) ;
  • Ahn, Jong-Woong (Division of Ocean Science, Korea Maritime University) ;
  • Lee, Burm-Jong (Department of Chemistry, Inje University) ;
  • Seo, Young-Wan (Division of Ocean Science, Korea Maritime University)
  • 발행 : 2004.03.31
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초록

As a part of our search for novel antioxidants from the seaweeds, we have investigated radical scavenging effect for their crude extracts using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, authentic peroxynitrite, and 3-morpholinsydnonimine (SIN-1), a peroxynitrite-generating species in vitro. Thirty-four seaweeds were screened for $ONOO^-$ and DPPH radical scavenging activities. A potent inhibitory effect against peroxynitrite generated by SIN-1 at $5{\mu}g/ml$ of methanol extracts was observed in order of Ishige okamurae(95.3%), Sargassum hemiphyllum(90.2%), Symphyocladia latiuscula(89.6%), Porphyra suborbiculata(86.7%), and Gelidium amamsii(85.9%), Also, a significant scavenging effect against direct authentic peroxynitrite was revekaled for methanol extracts of Ishige okamurae(66.2%) and Sargassum hemiphyllum(55.2%) and the acetone/methylene chloride(1:1) extract of Gigatina tenella (61.0%). In our measurement for evaluating the capacity to scavenge the stable free radical of DPPH, acetone/methylene chloride(1:1) extracts of Symphyocladia latiuscula, Gloiopeltis furcata, and Sargassum thunbergii and the methanol extract of Sargassum sp. showed an inhibitory potency of 85.8%, 82.8%, 74.1%, and 64.0%, respectively.

키워드

참고문헌

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피인용 문헌

  1. In vitro antioxidant properties of crude extracts and compounds from brown algae vol.138, pp.2-3, 2013, https://doi.org/10.1016/j.foodchem.2012.11.026
  2. Screening of Korean marine plants for their inhibitory effect on histamine release from RPMCin vitro vol.11, pp.1, 2006, https://doi.org/10.1007/BF02931873
  3. Photo-protective properties of Lomentaria hakodatensis yendo against ultraviolet B radiation-induced keratinocyte damage vol.17, pp.6, 2012, https://doi.org/10.1007/s12257-012-0336-3
  4. Antioxidants from macroalgae: potential applications in human health and nutrition vol.25, pp.4, 2010, https://doi.org/10.4490/algae.2010.25.4.155
  5. Antioxidant properties ofErigeron annuus extract and its three phenolic constituents vol.11, pp.1, 2006, https://doi.org/10.1007/BF02931862
  6. Antioxidant efficacy of extracts from a variety of seaweeds in a cellular system vol.43, pp.1, 2008, https://doi.org/10.1007/BF03022429
  7. Anti-obesity effects of seaweeds of Jeju Island on the differentiation of 3T3-L1 preadipocytes and obese mice fed a high-fat diet vol.90, 2016, https://doi.org/10.1016/j.fct.2016.01.023