Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Anti-Diabetic Activities of Fucosterol from Pelvetia siliquosa

  • Lee, Yeon-Sil (Seokwon Life Science Research Institute, World Sea Green Co. Ltd.) ;
  • Shin, Kuk-Hyun (Seokwon Life Science Research Institute, World Sea Green Co. Ltd.) ;
  • Kim, Bak-Kwang (College of Pharmacy, Seoul National University) ;
  • Lee, Sang-Hyun (College of Pharmacy, Seoul National University)
  • Published : 2004.11.01
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Abstract

Fucosterol isolated from Pelvetia siliquosa was tested for its anti-diabetic activity in vivo. Fucosterol, when administered orally at 30 mg/kg in streptozotocin-induced diabetic rats, was caused a significant decrease in serum glucose concentrations, and exhibited an inhibition of sorbitol accumulations in the lenses. Fucosterol, when administered orally at 300 mg/kg in epinephrine-induced diabetic rats, was also caused an inhibition of blood glucose level and glycogen degradation. These results demonstrated that fucosterol is a main anti-diabetic principle from the marine algae P. siliquosa.

Keywords

References

  1. Clements, R. S., Morrison, A. D., and Winegard, A. I., Polyol pathway in aorta: regulation by hormones. Science, 166, 1007-1008 (1969) https://doi.org/10.1126/science.166.3908.1007
  2. Drabkin, D. S. and Ausin, J. H., Spectrophotometric constants for common hemoglobin derivatives in human, dog, and rabbit blood. J. Biol. Chem., 98, 719 (1932)
  3. Johnson, J. A. and Fusaro, R. M., The quantitative enzymatic determination of animal liver glycogen. Anal. Biochem., 15, 140-149 (1966) https://doi.org/10.1016/0003-2697(66)90256-9
  4. Kreisman, S. H., Ah Mew, N., Arsenault, M., Nessim, S. J., Halter, J. B., Vranic, M., and Marliss, E. B., Epinephrine infusion during moderate intensity exercise increases glucose production and uptake. Am. J. Physiol. Endocrinol. Metab., 278, E949-E957 (2000) https://doi.org/10.1152/ajpendo.2000.278.5.E949
  5. Lee, S., Lee, Y. S., Jung, S. H., Kang, S. S., and Shin, K. H., Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa. Arch. Pharm. Res., 26, 719-722 (2003) https://doi.org/10.1007/BF02976680
  6. Mariam, A., Asmawi, M. Z., and Sadikun., Hypoglycemic activity of the aqueous extract of Orthosiphon stamineus. Fitoterapia, 57,465-468 (1996)
  7. Oh, Y. S., Lee, I. K., and Boo, S. M., An annotated account of Korean economic seaweeds for food, medical and industrial uses. Kor. J. Phycol., 5, 57-71 (1990)
  8. Trinder, P. Determination of glucose using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem., 6, 24-27 (1969) https://doi.org/10.1177/000456326900600108
  9. Yoon, J. T., Developmental morphology on the regeneration of Pelvetia siliquosa Tseng et Chang, Phaeophyta in Korea. Chonbuk National University. Ph. D. Thesis (1995)
  10. Lee, Y. S., Jung, S. H., Lee, S., Choi, Y. J., and Shin, K. H., Hepatoprotective and anti-diabetic effects of Pelvetia siliquosa, a marine algae, in rats. J. Appl. Pharmacol., 10, 165-169 (2002)